There are two vascular networks in mammals that coordinately function as the main supply
and drainage systems of the body. The blood vasculature carries oxygen, nutrients …

Visualizing the cell cycle behavior of individual cells within living organisms can facilitate the
understanding of developmental processes such as pattern formation, morphogenesis, cell …

Oligodendrocyte progenitor cells (OPCs), which differentiate into myelinating
oligodendrocytes during CNS development, are the main proliferative cells in the adult …

Complex neuronal circuitries such as those found in the mammalian cerebral cortex have
evolved as balanced networks of excitatory and inhibitory neurons. Although the …

Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving
tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by …

Acute kidney injury (AKI) is frequent, often fatal and, for lack of specific therapies, can leave
survivors with chronic kidney disease (CKD). We characterize the distribution of tubular cells …

During self-renewal, cell-type-defining features are drastically perturbed in mitosis and must
be faithfully reestablished upon G1 entry, a process that remains largely elusive. Here, we …

The most aggressive B cell lymphomas frequently manifest extranodal distribution and carry
somatic mutations in the poorly characterized gene TBL1XR1. Here, we show that TBL1XR1 …

Crescentic glomerulonephritis is characterized by vascular necrosis and parietal epithelial
cell hyperplasia in the space surrounding the glomerulus, resulting in the formation of …

Murine dermis contains functionally and spatially distinct fibroblast lineages that cease to
proliferate in early postnatal life. Here, we propose a model in which a negative feedback …