Protein arginine methyltransferase 6 (PRMT6) is a type I PRMT that is involved in epigenetic
regulation of gene expression through methylating histone or non-histone proteins, and …

Base excision repair (BER) corrects forms of oxidative, deamination, alkylation, and abasic
single-base damage that appear to have minimal effects on the helix. Since its discovery in …

Background: MYC is amplified in approximately 15% of breast cancers (BCs) and is
associated with poor outcome. c-MYC protein is multi-faceted and participates in many …

FEN1 has key roles in Okazaki fragment maturation during replication, long patch base
excision repair, rescue of stalled replication forks, maintenance of telomere stability and …

ATR-CHEK1 signalling is critical for genomic stability. ATR-CHEK1 signalling may be
deregulated in breast cancer and have prognostic, predictive and therapeutic significance …

Survival outcomes for patients with advanced ovarian cancer remain poor despite advances
in chemotherapy and surgery. Platinum-based systemic chemotherapy can result in a …

Alterations in DNA repair pathways are one of the main drivers of cancer insurgence.
Nevertheless, cancer cells are more susceptible to DNA damage than normal cells and they …

BRCA1, a key factor in homologous recombination (HR) repair may also regulate base
excision repair (BER). Targeting BRCA1-BER deficient cells by blockade of ATM and DNA …

DNA repair defects have been increasingly focused on as therapeutic targets. In hormone-
positive breast cancer, XRCC1-deficient tumors have been identified and proposed as …

DNA damage signaling response and repair (DDR) is a critical defense mechanism against
genomic instability. Impaired DNA repair capacity is an important risk factor for cancer …