14‐3‐3 Family of Proteins: Biological Implications, Molecular Interactions, and Potential Intervention in Cancer, Virus and Neurodegeneration Disorders
ABSTRACT The 14‐3‐3 family of proteins are highly conserved acidic eukaryotic proteins
(25–32 kDa) abundantly present in the body. Through numerous binding partners, the 14‐3 …
(25–32 kDa) abundantly present in the body. Through numerous binding partners, the 14‐3 …
[HTML][HTML] Harnessing the 14-3-3 protein–protein interaction network
P Pitasse-Santos, I Hewitt-Richards… - Current Opinion in …, 2024 - Elsevier
Protein–protein interactions (PPIs) play a critical role in cellular signaling and represent
interesting targets for therapeutic intervention. 14-3-3 proteins integrate many signaling …
interesting targets for therapeutic intervention. 14-3-3 proteins integrate many signaling …
[HTML][HTML] 14–3-3θ phosphorylation exacerbates alpha-synuclein aggregation and toxicity
B Wang, M Gannon, R Pattanayak, K Scholz… - Neurobiology of …, 2025 - Elsevier
Aggregation of alpha-synuclein (αsyn) plays an integral role in Parkinson's disease (PD)
and Dementia with Lewy bodies (DLB). 14–3-3θ is a highly expressed brain protein with …
and Dementia with Lewy bodies (DLB). 14–3-3θ is a highly expressed brain protein with …
14-3-3τ as a Modulator of Early α-Synuclein Multimerization and Amyloid Formation
G Heesink, MCM van den Oetelaar… - ACS chemical …, 2024 - ACS Publications
The aggregation of α-synuclein (αS) plays a key role in Parkinson's disease (PD) etiology.
While the onset of PD is age-related, the cellular quality control system appears to regulate …
While the onset of PD is age-related, the cellular quality control system appears to regulate …
Role of the Night-Time Systemic Processes and the Astrocyte Tryptophan-Melatonin Pathway in the Regulation of α-Synuclein and Wider Parkinson's Disease …
G Anderson - 2023 - preprints.org
An array of diverse processes and factors have been linked to the pathoetiology and
pathophysiology of Parkinson's disease (PD), including systemic CNS factors. This article …
pathophysiology of Parkinson's disease (PD), including systemic CNS factors. This article …