The transcription factor HIF1α is implicated in the development of clear cell renal cell
carcinoma (ccRCC). Although HIF1α was initially believed to be essential for ccRCC …

Introduction: Unresectable renal cell carcinoma (RCC) is a technically incurable condition.
Historically, RCC is resistant to chemotherapy and radiotherapy. Cytokine therapy was until …

Here we found that dual mTORC1/2 inhibitor AZD-2014 significantly inhibited RCC cell
survival and growth, with higher efficiency than conventional mTORC1 inhibitors rapamycin …

Purpose To assess the value of arterial spin-labeling (ASL) perfusion magnetic resonance
(MR) imaging in the characterization of solid renal masses by using histopathologic findings …

Background Clear cell renal cell carcinoma (ccRCC), the most aggressive renal cancer, is
characterized by early lymph node metastases and bad prognosis. Most therapies targeting …

Background The expression of inducible nitric oxide synthase (iNOS) and vascular
endothelial growth factor (VEGF) and the level of total oxyradical scavenging capacity have …

Hereditary and sporadic renal cell carcinomas (RCCs) are often associated with Von Hippel-
Lindau (VHL)-gene inactivation. Patients with VHL disease have an increased risk of RCC …

Hepatocellular carcinoma (HCC) is resistant to chemotherapy. Recently, however, several
oxaliplatin‐based combinatorial treatments have shown a promising anti‐tumor activity in …

The need for effective targeted therapies for renal cell carcinomas (RCCs) has fueled the
interest for understanding molecular pathways involved in the oncogenesis of kidney …

OBJECTIVE: In order to perform effective translational research for cancer therapy, we need
to employ pre-clinical models which reflect the clinical situation. The purpose of this study …