Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

Diabetic cognitive impairment (DCI) is a complex complication of diabetes in the central
nervous system, and its pathological mechanism is still being explored. Astrocytes are …

Based on the concept of the tripartite synapse, we have reviewed the role of glucose-derived
compounds in glycolytic pathways in astroglial cells. Glucose provides energy and substrate …

Rheumatoid arthritis (RA) is a chronic inflammatory, autoimmune disease that gradually
affects the synovial membrane and joints. Many intrinsic and/or extrinsic factors are crucial in …

Metformin, a biguanide compound (N-1, 1-dimethylbiguanide), is widely prescribed for
diabetes mellitus type 2 (T2D) treatment. It also presents a plethora of properties, such as …

While it is well-acknowledged that neurovascular dysfunction in hypertension is tightly
associated with accelerated brain aging, we contend that the deleterious effects of …

Methylglyoxal (MG), a potent glycotoxin that can be found in the diet, is one of the main
precursors of Advanced glycation end products (AGEs). It is well known that modifications in …

Methylglyoxal (MGO) is an endogenous toxin, mainly produced as a by-product of glycolysis
that has been associated to aging, Alzheimer's disease, and inflammation. Cell culture …

Methylglyoxal (MG) is a reactive dicarbonyl compound formed mostly via the glycolytic
pathway. Elevated blood glucose levels can cause MG accumulation in plasma and …

Methylglyoxal (MG) is a by-product of glycolysis. In pathological conditions, particularly
diabetes mellitus, this molecule is unbalanced, causing widespread protein glycation. In …