Age-related hearing loss (ARHL) is a common, increasing problem for older adults, affecting
about 1 billion people by 2050. We aim to correlate the different reductions of hearing from …

The auditory brainstem response (ABR) is a sound-evoked noninvasively measured
electrical potential representing the sum of neuronal activity in the auditory brainstem and …

Kv3 potassium currents mediate rapid repolarisation of action potentials (APs), supporting
fast spikes and high repetition rates. Of the four Kv3 gene family members, Kv3. 1 and Kv3. 3 …

The calyx of Held is the preeminent model for the study of synaptic function in the
mammalian CNS. Despite much work on the synapse and associated circuit, its role in …

Acoustic startle response (ASR) modification procedures, especially prepulse inhibition
(PPI), are increasingly used as behavioral measures of auditory processing and …

Localization of sound sources is a central aspect of auditory processing. A unique feature of
mammals is the smooth, tonotopically organized extension of the hearing range to high …

Neuronal origins of behavioral disorders have been examined for decades to construct
frameworks for understanding psychiatric diseases and developing useful therapeutic …

During development, the organization of the auditory system into distinct functional
subcircuits depends on the spatially and temporally ordered sequence of neuronal …

The medial nucleus of the trapezoid body (MNTB) is a collection of brainstem neurons that
function within the ascending auditory pathway. MNTB neurons are associated with a …

Key points During the computation of sound localization, neurons of the lateral superior olive
(LSO) integrate synaptic excitation arising from the ipsilateral ear with inhibition from the …