Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

In the mammalian cerebral cortex neurons are arranged in specific layers and form
connections both within the cortex and with other brain regions, thus forming a complex …

Realizing the full utility of brain organoids to study human development requires
understanding whether organoids precisely replicate endogenous cellular and molecular …

Extrinsic signaling between diverse cell types is crucial for nervous system development.
Ligand binding is a key driver of developmental processes. Nevertheless, it remains a …

Precise temporal control of gene expression in neuronal progenitors is necessary for correct
regulation of neurogenesis and cell fate specification. However, the cellular heterogeneity of …

The coordinated spatial and temporal regulation of gene expression in the vertebrate neural
tube determines the identity of neural progenitors and the function and physiology of the …

The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types
arranged in characteristic positions. During development, these different types of neurons …

Astrocytes have in recent years become the focus of intense experimental interest, yet
markers for their definitive identification remain both scarce and imperfect. Astrocytes may …

Glioblastoma (GBM) is a devastating human malignancy. GBM stem-like cells (GSCs) drive
tumor initiation and progression. Yet the molecular determinants defining GSCs in their …

Sox transcription factors play widespread roles during development; however, their versatile
funtions have a relatively simple basis: the binding of a Sox protein alone to DNA does not …