Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine encoded within a
functionally polymorphic genetic locus. MIF was initially recognized as a cytokine generated …

Infections represent a common health problem in people of all ages. Usually, the response
given to them is appropriate and so little treatment is needed. Sometimes, however, the …

The immune response to sepsis can be seen as a pattern recognition receptor-mediated
dysregulation of the immune system following pathogen invasion in which a careful balance …

Sepsis is among the most common causes of death in hospitals. It arises from the host
response to infection. Currently, diagnosis relies on nonspecific physiological criteria and …

Introduction The current shortage of accurate and readily available, validated biomarkers of
disease severity in sepsis is an important limitation when attempting to stratify patients into …

Macrophage migration inhibitory factor (MIF) exerts multiple effects on immune cells, as well
as having functions outside the immune system. MIF can promote inflammation through the …

The majority of bacteremias do not develop to sepsis: bacteria are cleared from the
bloodstream. Oxygen released from erythrocytes and humoral immunity kill bacteria in the …

Introduction Accurate and timely diagnosis of community-acquired bacterial infections in
patients with systemic inflammation remains challenging both for clinician and laboratory …

Sepsis remains a leading cause of death in critically ill patients, despite efforts to improve
patient outcome. Thus far, no magic drugs exist for severe sepsis and septic shock. Instead …

Macrophage migration inhibitory (MIF) factor is an immunoregulatory cytokine whose effect
on arresting random immune cell movement was recognized several decades ago. Despite …