Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-
renewal potentials. MSCs-based therapies have been widely utilized for the treatment of …

Cancer cells resistance to various therapies remains to be a key challenge nowadays. For a
long time, scientists focused on tumor cells themselves for the mechanisms of acquired drug …

Background Metastatic colonization is one of the critical steps in tumor metastasis. A pre-
metastatic niche is required for metastatic colonization and is determined by tumor-stroma …

The interaction between tumor cells and non-malignant hosts cells within the tumor
microenvironment (TME) is critical to the pathophysiology of cancer. These non-malignant …

For a long period, cancer has been believed to be a gene disease, in which oncogenic and
suppressor mutations accumulate gradually, finally leading to the malignant transformation …

Background Sorafenib (SOR) is the first line treatment for advanced hepatocellular
carcinoma (HCC), but resistance develops frequently. Tumor-associated macrophages …

Simple Summary Normal epithelial cells in our organs are surrounded by stroma, which is
an ecosystem made up of a variety of cells and proteins that support their intended functions …

Pancreatic ductal adenocarcinoma (PDAC) is associated with an incredibly dense stroma,
which contributes to its recalcitrance to therapy. Cancer-associated fibroblasts (CAFs) are …

Background Breast cancer is the most frequently diagnosed cancer and a common cause of
cancer-related death in women. It is well recognized that obesity is associated with an …

Autophagy-mediated chemoresistance is the core mechanism for therapeutic failure and
poor prognosis in breast cancer. Breast cancer chemotherapy resistance is believed to be …