[HTML][HTML] Single-cell technologies: a new lens into epigenetic regulation in development
Highlights•Single-cell atlases of mouse embryogenesis reveal epigenetic regulator
dynamics in early development.•Genetic perturbation in combination with single-cell …
dynamics in early development.•Genetic perturbation in combination with single-cell …
Reconstructing axial progenitor field dynamics in mouse stem cell-derived embryoids
Embryogenesis requires substantial coordination to translate genetic programs to the
collective behavior of differentiating cells, but understanding how cellular decisions control …
collective behavior of differentiating cells, but understanding how cellular decisions control …
Hypoxia induces an early primitive streak signature, enhancing spontaneous elongation and lineage representation in gastruloids
The cellular microenvironment, together with intrinsic regulators, shapes stem cell identity
and differentiation capacity. Mammalian early embryos are exposed to hypoxia in vivo and …
and differentiation capacity. Mammalian early embryos are exposed to hypoxia in vivo and …
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in stembryos
A Villaronga Luque, RG Savill, N López-Anguita… - bioRxiv, 2023 - biorxiv.org
Mammalian stem-cell-based models of embryo development (stembryos) hold great promise
in basic and applied research. However, considerable phenotypic variation despite identical …
in basic and applied research. However, considerable phenotypic variation despite identical …
Inferring cell differentiation maps from lineage tracing data
During development, mulitpotent cells differentiate through a hierarchy of increasingly
restricted progenitor cell types until they realize specialized cell types. A cell differentiation …
restricted progenitor cell types until they realize specialized cell types. A cell differentiation …
Generation and molecular characterization of mouse embryonic stem cells derived Trunk-Like Structures
A Bolondi - 2022 - refubium.fu-berlin.de
One of the greatest mysteries in developmental biology is how the orchestrated process of
cellular differentiation guides a single cell to form a functional organism comprised of …
cellular differentiation guides a single cell to form a functional organism comprised of …
[PDF][PDF] Hypoxia induces an early primitive streak signature, enhancing spontaneous elongation and lineage representation in gastruloids
D Conkar, M Typou, R Buschow, JV Veenvliet… - 2022 - academia.edu
The cellular microenvironment, together with intrinsic regulators, shapes stem cell identity
and differentiation capacity. Mammalian early embryos are exposed to hypoxia in vivo and …
and differentiation capacity. Mammalian early embryos are exposed to hypoxia in vivo and …