Drug-induced liver injury

RJ Andrade, N Chalasani, ES Björnsson… - Nature Reviews …, 2019 - nature.com
Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that
occurs either as a predictable event when an individual is exposed to toxic doses of some …

Drug induced liver injury: an update

M Garcia-Cortes, M Robles-Diaz, C Stephens… - Archives of …, 2020 - Springer
Drug induced liver injury (DILI) is a relatively rare hepatic condition in response to the use of
medications, illegal drugs, herbal products or dietary supplements. It occurs in susceptible …

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

RJ Fontana, I Liou, A Reuben, A Suzuki, MI Fiel… - Hepatology, 2023 - journals.lww.com
There are currently more than 1000 prescription medications available for use in the United
States and more than 100,000 over-the-counter herbal and dietary supplements (HDS) …

EASL clinical practice guidelines: drug-induced liver injury

RJ Andrade, GP Aithal, ES Björnsson, N Kaplowitz… - Journal of …, 2019 - Elsevier
Idiosyncratic (unpredictable) drug-induced liver injury is one of the most challenging liver
disorders faced by hepatologists, because of the myriad of drugs used in clinical practice …

Drug-induced liver injury: recent advances in diagnosis and risk assessment

GA Kullak-Ublick, RJ Andrade, M Merz, P End… - Gut, 2017 - gut.bmj.com
Idiosyncratic drug-induced liver injury (IDILI) is a rare but potentially severe adverse drug
reaction that should be considered in patients who develop laboratory criteria for liver injury …

Drug-induced liver injury: Asia Pacific Association of Study of Liver consensus guidelines

H Devarbhavi, G Aithal, S Treeprasertsuk… - Hepatology …, 2021 - Springer
Idiosyncratic drug-induced liver injury mimics acute and chronic liver disease. It is under
recognized and underrecognised because of the lack of pathognomonic diagnostic …

Scoring systems for predicting mortality for severe patients with COVID-19

Y Shang, T Liu, Y Wei, J Li, L Shao, M Liu… - …, 2020 - thelancet.com
Abstract Background Coronavirus disease 2019 (COVID-19) has been widely spread and
caused tens of thousands of deaths, especially in patients with severe COVID-19. This …

[HTML][HTML] Comprehensive analysis and insights gained from long-term experience of the Spanish DILI Registry

C Stephens, M Robles-Diaz, I Medina-Caliz… - Journal of …, 2021 - Elsevier
Background & Aims Prospective drug-induced liver injury (DILI) registries are important
sources of information on idiosyncratic DILI. We aimed to present a comprehensive analysis …

[HTML][HTML] Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives

A Ramachandran, RGJ Visschers, L Duan… - Journal of clinical and …, 2018 - ncbi.nlm.nih.gov
Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …

Hepatotoxicity of statins and other lipid‐lowering agents

ES Björnsson - Liver International, 2017 - Wiley Online Library
Statins are generally well tolerated and adverse effects are relatively rare. Clinical trials are
underpowered to detect uncommon adverse effects such as idiosyncratic drug‐induced liver …