Mitochondrial DNA (mtDNA) faces the universal challenges of genome maintenance: the
accurate replication, transmission and preservation of its integrity throughout the life of the …

Aging has been associated with damage accumulation in the genome and with increased
cancer incidence. Reactive oxygen species (ROS) are produced from endogenous sources …

Base excision repair (BER) is an evolutionarily conserved process for maintaining genomic
integrity by eliminating several dozen damaged (oxidized or alkylated) or inappropriate …

▪ Abstract Living organisms dependent on water and oxygen for their existence face the
major challenge of faithfully maintaining their genetic material under a constant attack from …

The mitochondrion was originally a free-living prokaryotic organism, which explains the
presence of a compact mammalian mitochondrial DNA (mtDNA) in contempory mammalian …

▪ Abstract Any living cell is faced with the fundamental task of keeping the genome intact in
order to develop in an organized manner, to function in a complex environment, to divide at …

▪ Abstract DNA polymerase (pol) γ is the sole DNA polymerase in animal mitochondria.
Biochemical and genetic evidence document a key role for pol γ in mitochondrial DNA …

Exposure to exogenous and endogenous sources cause oxidative damage to cellular
macromolecules, including DNA. This results in gradual accumulation of oxidative DNA …

Alterations in expression of mitochondrial DNA (mtDNA)-encoded polypeptides required for
oxidative phosphorylation and cellular ATP generation may be a general characteristic of …

DNA, single-strand breaks SSBs can play havoc with replication and transcription if not
efficiently eliminated. Breaks arise spontaneously during normal metabolism from direct …