Recent developments in asymmetric phase‐transfer reactions

S Shirakawa, K Maruoka - Angewandte Chemie International …, 2013 - Wiley Online Library
Phase‐transfer catalysis has been recognized as a powerful method for establishing
practical protocols for organic synthesis, because it offers several advantages, such as …

Neue Entwicklungen bei asymmetrischen Phasentransferreaktionen

S Shirakawa, K Maruoka - Angewandte Chemie, 2013 - Wiley Online Library
Die Phasentransferkatalyse bildet eine effiziente Grundlage zur Einführung praktischer
Methoden in die organische Synthese, denn sie bietet mehrere Vorteile wie einfache …

Stereodivergent α-allylation of linear aldehydes with dual iridium and amine catalysis

S Krautwald, MA Schafroth, D Sarlah… - Journal of the …, 2014 - ACS Publications
We describe the fully stereodivergent, dual catalytic α-allylation of linear aldehydes. The
reaction proceeds via direct iridium-catalyzed substitution of racemic allylic alcohols with …

Enantioselective synthesis of chiral piperidines via the stepwise dearomatization/borylation of pyridines

K Kubota, Y Watanabe, K Hayama… - Journal of the American …, 2016 - ACS Publications
We have developed a novel approach for the synthesis of enantioenriched 3-boryl-
tetrahydropyridines via the Cu (I)-catalyzed regio-, diastereo-, and enantioselective …

Unveiling the Stereoselectivity Aspects of Metallaphotoredox Decarboxylative Arylation

R Nallagonda, R Quan, L Grant, C Jorge, S Yip… - ACS …, 2024 - ACS Publications
Decarboxylative cross-coupling methodologies are now widely employed in pharmaceutical
drug discovery research, forming the basis of strategic retrosynthetic analysis and radical …

Multigram-scale flow synthesis of the chiral key intermediate of (−)-paroxetine enabled by solvent-free heterogeneous organocatalysis

SB Ötvös, MA Pericàs, CO Kappe - Chemical Science, 2019 - pubs.rsc.org
The catalytic enantioselective synthesis of the chiral key intermediate of the antidepressant
(−)-paroxetine is demonstrated as a continuous flow process on multi-gram scale. The …

Iron-catalyzed oxidative C (3)–H functionalization of amines

N Takasu, K Oisaki, M Kanai - Organic letters, 2013 - ACS Publications
Fe-catalyzed direct dehydrogenative C (3)-functionalization of tertiary arylamines was
developed via activation of the sp3 C (3)–H bond. The reaction is applicable to both cyclic …

Electro-oxidative C–H amination of heteroarenes with aniline derivatives via radical–radical cross coupling

X Peng, J Zhao, G Ma, Y Wu, S Hu, Z Ruan, P Feng - Green Chemistry, 2021 - pubs.rsc.org
The selective synthesis of C-2/C-3 aminated five-membered heteroarenes incorporated
various functionalities with aniline derivatives in a sustainable way remains an unmet …

Synthesis of chiral heterocycles by ligand-controlled regiodivergent and enantiospecific Suzuki Miyaura cross-coupling

J Ding, T Rybak, DG Hall - Nature Communications, 2014 - nature.com
Non-aromatic nitrogen-and oxygen-containing heterocycles such as piperidines and pyrans
are prevalent components of natural products and pharmaceutical drugs. Although it has …

Organocatalytic Michael and Friedel–Crafts reactions in enantioselective synthesis of biologically active compounds

OV Maltsev, IP Beletskaya… - Russian Chemical Reviews, 2011 - iopscience.iop.org
Recent applications of organocatalytic Michael and Friedel–Crafts reactions in
enantioselective synthesis of biologically active compounds: natural products …