Bruton's tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic
signaling that is critical for proliferation and survival of leukemic cells in many B cell …

B cells develop from hematopoietic precursor cells in an ordered maturation and selection
process. Extensive studies with many different mouse mutants provided fundamental …

Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and
functions as an important regulator of cell proliferation and cell survival in various B cell …

Immune dysregulation plays a vital role in colorectal cancer initiation and progression. Long
noncoding RNAs (lncRNA) exhibit multiple functions including regulation of gene …

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …

B cells differentiate from pluripotent hematopoietic stem cells (pHSCs) in a series of distinct
stages. During early embryonic development, pHSCs migrate into the fetal liver, where they …

The B cell receptor (BCR) and its precursor (pre-BCR) control B cell homeostasis,
differentiation and function. Moreover, aberrant pre-BCR and BCR signalling have a central …

The pre-B-cell receptor (pre-BCR) is expressed following the productive recombination of
the immunoglobulin heavy chain gene. Signals through the pre-BCR are required for …

Antigen receptors on the surface of B lymphocytes trigger adaptive immune responses after
encountering their cognate antigens but also control a series of antigen-independent …

SH2 domains are interaction modules uniquely dedicated to the recognition of
phosphotyrosine sites and are embedded in proteins that couple protein-tyrosine kinases to …