Oxidative stress is a normal phenomenon in the body. Under normal conditions, the
physiologically important intracellular levels of reactive oxygen species (ROS) are …

Background: We aimed to assess general practitioners'(GPs) knowledge, attitudes, and
practices (KAPs) toward screening recommendation guidelines of the United States …

Highlights•Oxidative stress is an etiopathogenic event upstream to Aβ-plaques and
neurofibrillary tangles leading to Alzheimer's disease.•Unquenched ROS perturb the …

Neutrophils have long been considered simple suicide killers at the bottom of the hierarchy
of the immune response. That view began to change 10–20 yr ago, when the sophisticated …

For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

Although the central role of the phagocytic NADPH oxidase in mediating bacterial killing has
long been appreciated, this sophisticated enzyme complex serves various other important …

The production of reactive oxygen species (ROS) within immune cell phagosomes is critical
for antimicrobial activity and for correct antigen processing, and influences signaling …

This review focuses on the sequence of cellular events leading to calcium signals critical for
phagosome maturation. Immune cells kill microbes by engulfing them in a membrane …

Neutrophils kill microbes with reactive oxygen species generated by the NADPH oxidase, an
enzyme which moves electrons across membranes. Voltage-gated proton channels (voltage …

The classical model of bacterial killing by phagocytic cells has been recently challenged by
questioning the toxic effect of oxygen products and attributing the fundamental role to K+ …