Current status and applications of genome-scale metabolic models

C Gu, GB Kim, WJ Kim, HU Kim, SY Lee - Genome biology, 2019 - Springer
Genome-scale metabolic models (GEMs) computationally describe gene-protein-reaction
associations for entire metabolic genes in an organism, and can be simulated to predict …

Designing microbial cell factories for the production of chemicals

JS Cho, GB Kim, H Eun, CW Moon, SY Lee - Jacs Au, 2022 - ACS Publications
The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …

Recent advances in systems and synthetic biology approaches for developing novel cell-factories in non-conventional yeasts

P Patra, M Das, P Kundu, A Ghosh - Biotechnology Advances, 2021 - Elsevier
Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …

MetaNetX/MNXref: unified namespace for metabolites and biochemical reactions in the context of metabolic models

S Moretti, VDT Tran, F Mehl, M Ibberson… - Nucleic acids …, 2021 - academic.oup.com
MetaNetX/MNXref is a reconciliation of metabolites and biochemical reactions providing
cross-links between major public biochemistry and Genome-Scale Metabolic Network …

Metabolic engineering in the host Yarrowia lipolytica

AM Abdel-Mawgoud, KA Markham, CM Palmer… - Metabolic …, 2018 - Elsevier
The nonconventional, oleaginous yeast, Yarrowia lipolytica is rapidly emerging as a
valuable host for the production of a variety of both lipid and nonlipid chemical products …

Reconstruction of a catalogue of genome-scale metabolic models with enzymatic constraints using GECKO 2.0

I Domenzain, B Sánchez, M Anton… - Nature …, 2022 - nature.com
Genome-scale metabolic models (GEMs) have been widely used for quantitative exploration
of the relation between genotype and phenotype. Streamlined integration of enzyme …

[HTML][HTML] Synthetic biology tools for engineering Yarrowia lipolytica

M Larroudé, T Rossignol, JM Nicaud… - Biotechnology …, 2018 - Elsevier
The non-conventional oleaginous yeast Yarrowia lipolytica shows great industrial promise. It
naturally produces certain compounds of interest but can also artificially generate non-native …

Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability

C Jo, J Zhang, JM Tam, GM Church, AS Khalil… - Materials Today Bio, 2023 - Elsevier
Filamentous fungi drive carbon and nutrient cycling across our global ecosystems, through
its interactions with growing and decaying flora and their constituent microbiomes. The …

Host-mycobiome metabolic interactions in health and disease

N Begum, A Harzandi, S Lee, M Uhlen, DL Moyes… - Gut …, 2022 - Taylor & Francis
Fungal communities (mycobiome) have an important role in sustaining the resilience of
complex microbial communities and maintenance of homeostasis. The mycobiome remains …

Synthetic biology, systems biology, and metabolic engineering of Yarrowia lipolytica toward a sustainable biorefinery platform

J Ma, Y Gu, M Marsafari, P Xu - … : Official Journal of the Society for …, 2020 - academic.oup.com
Yarrowia lipolytica is an oleaginous yeast that has been substantially engineered for
production of oleochemicals and drop-in transportation fuels. The unique acetyl …