Liver cirrhosis is an increasing health burden and public health concern. Regardless of
etiology, patients with cirrhosis are at risk of a range of life-threatening complications …

Current computational workflows for comparative analyses of single-cell datasets typically
use discrete clusters as input when testing for differential abundance among experimental …

Despite major advances in immunotherapy, hepatocellular carcinoma (HCC) remains a
challenging target. Natural Killer (NK) cells are crucial components of the anti-HCC immune …

Ficolins are innate pattern recognition receptors (PRR) and play integral roles within the
innate immune response to numerous pathogens throughout the circulation, as well as …

Innate immunity contributes effectively to the development of Alcohol-Associated liver
disease (ALD). Particularly, human studies and murine models of ALD have shown that …

Background and Aims Given the lack of effective therapies and high mortality in acute
alcohol‐associated hepatitis (AH), it is important to develop rationally designed biomarkers …

Single-cell omic protocols applied to disease, development or mechanistic studies can
reveal the emergence of aberrant cell states or changes in differentiation. These …

Background There is an unstable balance between pro-and anti-haemostatic processes in
patients with cirrhosis. We hypothesized, that in patients with acute decompensation (AD) …

Background Alcoholism associates with increased Staphylococcus aureus bacteremia
incidence and mortality. The objective was to compare disease progression, treatment and …

Background and aim: Patients with liver cirrhosis and ascites have a poor prognosis with
increased risk of infection related death, as advanced stages of cirrhosis are associated with …