Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to
tackle disease-causing proteins that have historically been highly challenging to target with …

Targeted protein degradation (TPD) strategies have revolutionized how scientists tackle
challenging protein targets deemed undruggable with traditional small molecule inhibitors …

A fundamental prerequisite for the efficacy of cancer immunotherapy is the presence of
functional, antigen-specific T cells within the tumor. Neoantigen-directed therapy is a …

With the discovery of PROteolysis TArgeting Chimeras (PROTACs) twenty years ago,
targeted protein degradation (TPD) has changed the landscape of drug development …

Tumor-infiltrating regulatory T lymphocytes (Treg) can suppress effector T cells specific for
tumor antigens. Deeper molecular definitions of tumor-infiltrating-lymphocytes could thus …

Non-small-cell lung cancer (NSCLC) represents a heterogeneous group of malignancies
consisting essentially of adenocarcinoma (ADC) and squamous cell carcinoma (SCC) …

Therapeutic interventions to harness the immune system against tumor cells have provided
mixed results in the past for several solid tumors and hematologic malignancies. However …

Tumour-specific antigens have been an area of interest in cancer therapy since their
discovery in the middle of the 20th century. In the era of immune-based cancer therapeutics …

Schizophrenia is a debilitating psychiatric disorder that affects millions of people worldwide;
however, its etiology is poorly understood at the molecular and neurobiological levels. A …

Simple Summary Aberrant DNA methylation is associated with multiple malignancies,
including lung cancer. Differences in methylation patterns have been observed across lung …