Neuropeptides are found in many mammalian CNS neurons where they play key roles in
modulating neuronal activity. In contrast to amino acid transmitter release at the synapse …

Abstract G protein-gated K+(GIRK, or Kir3) channels mediate inhibitory neurotransmission
via G protein-coupled receptors (GPCRs) in heart and brain. The signaling cascade involves …

The Kir3. 1 K+ channel participates in heart rate control and neuronal excitability through G‐
protein and lipid signaling pathways. Expression in Escherichia coli has been achieved by …

Activation of the TRPM8 ion channel in sensory nerve endings produces a sensation of
pleasant coolness. Here we show that inflammatory mediators such as bradykinin and …

Two-pore-domain K+ channels provide neuronal background currents that establish resting
membrane potential and input resistance; their modulation provides a prevalent mechanism …

G protein-coupled receptors (GPCRs) respond to agonists to activate downstream enzymatic
pathways or to gate ion channel function. Turning off GPCR signaling is known to involve …

Addiction is a chronic disorder in which consumption of a substance or a habitual behavior
becomes compulsive and often recurrent, despite adverse consequences. Substance p (SP) …

Spinal projection neurons convey nociceptive signals to multiple brain regions including the
parabrachial (PB) nucleus, which contributes to the emotional valence of pain perception …

A large number of ion channels maintain their activity through direct interactions with
phosphatidylinositol bisphosphate (PIP2). For such channels, hydrolysis of PIP2 causes …

RGS3 and RGS4 are GTPase-activating proteins expressed in the brain and heart that
accelerate the termination of G i/o-and G q-mediated signaling. We report here the …