RNA-binding proteins and their role in kidney disease

L Seufert, T Benzing, M Ignarski… - Nature Reviews …, 2022 - nature.com
RNA-binding proteins (RBPs) are of fundamental importance for post-transcriptional gene
regulation and protein synthesis. They are required for pre-mRNA processing and for RNA …

Uncovering viral RNA–host cell interactions on a proteome-wide scale

L Iselin, N Palmalux, W Kamel, P Simmonds… - Trends in biochemical …, 2022 - cell.com
RNA viruses interact with a wide range of cellular RNA-binding proteins (RBPs) during their
life cycle. The prevalence of these host–virus interactions has been highlighted by new …

Global analysis of protein-RNA interactions in SARS-CoV-2-infected cells reveals key regulators of infection

W Kamel, M Noerenberg, B Cerikan, H Chen… - Molecular cell, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19). SARS-CoV-2 relies on cellular RNA-binding proteins (RBPs) to …

[HTML][HTML] RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks

S Zhao, J Cordes, KM Caban, MJ Götz… - Molecular cell, 2023 - cell.com
Reactive aldehydes are abundant endogenous metabolites that challenge homeostasis by
crosslinking cellular macromolecules. Aldehyde-induced DNA damage requires repair to …

K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution

AS Rahmanto, CJ Blum, C Scalera, JB Heidelberger… - Molecular Cell, 2023 - cell.com
Reactive aldehydes are produced by normal cellular metabolism or after alcohol
consumption, and they accumulate in human tissues if aldehyde clearance mechanisms are …

[HTML][HTML] Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles

W Kamel, V Ruscica, A Embarc-Buh, ZR de Laurent… - Molecular Cell, 2024 - cell.com
RNA is a central molecule for viruses; however, the interactions that viral RNA (vRNA)
establishes with the host cell is only starting to be elucidated. Here, we determine the …

The RNA-binding protein landscapes differ between mammalian organs and cultured cells

JI Perez-Perri, D Ferring-Appel, I Huppertz… - Nature …, 2023 - nature.com
Abstract System-wide approaches have unveiled an unexpected breadth of the RNA-bound
proteomes of cultured cells. Corresponding information regarding RNA-binding proteins …

SHIFTR enables the unbiased identification of proteins bound to specific RNA regions in live cells

J Aydin, A Gabel, S Zielinski, S Ganskih… - Nucleic Acids …, 2024 - academic.oup.com
RNA-protein interactions determine the cellular fate of RNA and are central to regulating
gene expression outcomes in health and disease. To date, no method exists that is able to …

From genes to traits: Trends in RNA-binding proteins and their role in plant trait development: A review

S Rehman, S Bahadur, W Xia, C Runan, M Ali… - International Journal of …, 2024 - Elsevier
RNA-binding proteins (RBPs) are essential for cellular functions by attaching to RNAs,
creating dynamic ribonucleoprotein complexes (RNPs) essential for managing RNA …

Cross-linking and mass spectrometry as a tool for studying the structural biology of ribonucleoproteins

CP Sarnowski, M Bikaki, A Leitner - Structure, 2022 - cell.com
Cross-linking and mass spectrometry (XL-MS) workflows represent an increasingly popular
technique for low-resolution structural studies of macromolecular complexes. Cross-linking …