Obesity challenges lipid and carbohydrate metabolism. The resulting glucolipotoxicity
causes endoplasmic reticulum (ER) dysfunction, provoking the accumulation of immature …

Obesity is a chronic disease resulting from multifactorial causes mainly related to lifestyle
(sedentary lifestyle, inadequate eating habits) and to other conditions such as genetic …

We evaluated the influence of the hyperglycemic intrauterine environment and postweaning
consumption of a high-fat diet (HFD) on the glycemia, insulin, lipid, and immunological …

Sugar-induced metabolic imbalances are a major health problem since an excessive
consumption of saccharides has been linked to greater obesity rates at a global level …

High-fat and high-sugar diets contribute to the prevalence of type 2 diabetes and
Alzheimer's disease (AD). Although the impact of high-fat diets on AD pathogenesis has …

Patients with diabetes have an increased risk of developing heart failure, preceded by (often
asymptomatic) cardiac abnormalities, collectively called diabetic cardiomyopathy (DC) …

Nonalcoholic steatohepatitis (NASH) is one of the important liver diseases currently
attracting attention in liver research and drug development. Appropriate mouse models …

Background Endoplasmic reticulum (ER) stress, promoting lipid metabolism disorders and
steatohepatitis, contributes significantly to the pathogenesis of nonalcoholic fatty liver …

Dietary sugar is an important determinant of the development and progression of
nonalcoholic fatty liver disease (NAFLD). However, the molecular mechanisms underlying …

During the periparturient transition period, negative energy balance (NEB) characterized by
high concentrations of non-esterified fatty acids (NEFA) may cause fatty liver and ketosis in …