Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …

Wheat is a major cereal crop providing energy and nutrients to the billions of people around
the world. Gluten is a structural protein in wheat, that is necessary for its dough making …

The oral delivery of proteins and peptides is a dynamic research field despite the numerous
challenges limiting their effective delivery. Successful oral delivery of proteins and peptides …

Background & Aims Partially degraded gluten peptides from cereals trigger celiac disease
(CD), an autoimmune enteropathy occurring in genetically susceptible persons …

The epithelial tight junction determines the paracellular water and ion movement in the
intestine and also prevents uptake of larger molecules, including antigens, in an …

In celiac disease (CD) a T-cell–mediated response to gluten is mounted in genetically
predisposed individuals, resulting in a malabsorptive enteropathy histologically highlighted …

Oral administration is the preferred route of drug delivery in clinical practice due to its
noninvasiveness, safety, convenience, and high patient compliance. The gastrointestinal …

Celiac disease (CeD) is an immune-mediated enteropathy, and unique in that the specific
trigger is known: gluten. The current mainstay of therapy is a gluten-free diet (GFD). As novel …

Celiac disease is an autoimmune disorder in which ingestion of dietary gluten triggers an
immune reaction in the small intestine leading to destruction of the lining epithelium. Current …

Celiac disease (CeD) is a frequent immune-mediated disease that affects not only the small
intestine but also many extraintestinal sites. The role of gluten proteins as dietary triggers …