KSHV: pathways to tumorigenesis and persistent infection

L Giffin, B Damania - Advances in virus research, 2014 - Elsevier
Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8) is
the etiologic agent of Kaposi's sarcoma, primary effusion lymphoma, and multicentric …

Molecular biology of KSHV lytic reactivation

P Purushothaman, T Uppal, SC Verma - Viruses, 2015 - mdpi.com
Kaposi's sarcoma-associated herpesvirus (KSHV) primarily persists as a latent episome in
infected cells. During latent infection, only a limited number of viral genes are expressed that …

The role of Kaposi sarcoma‐associated herpesvirus in the pathogenesis of Kaposi sarcoma

S Gramolelli, TF Schulz - The Journal of pathology, 2015 - Wiley Online Library
Kaposi sarcoma (KS) is an unusual vascular tumour caused by an oncogenic‐herpesvirus,
Kaposi sarcoma‐associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV …

Array-based transcript profiling and limiting-dilution reverse transcription-PCR analysis identify additional latent genes in Kaposi's sarcoma-associated herpesvirus

S Chandriani, D Ganem - Journal of virology, 2010 - Am Soc Microbiol
Kaposi's sarcoma-associated herpesvirus (KSHV) is a B-lymphotropic herpesvirus strongly
linked to both lymphoproliferative diseases and Kaposi's sarcoma. The viral latency program …

KSHV-mediated angiogenesis in tumor progression

P Purushothaman, T Uppal, R Sarkar, SC Verma - Viruses, 2016 - mdpi.com
Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus
(KSHV), is a malignant human oncovirus belonging to the gamma herpesvirus family. HHV-8 …

Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus

C Aresté, DJ Blackbourn - Trends in microbiology, 2009 - cell.com
The most recently identified human herpesvirus is Kaposi's sarcoma-associated herpesvirus
(KSHV). It causes Kaposi's sarcoma, a tumour occurring most commonly in untreated AIDS …

The M type K15 protein of Kaposi's sarcoma-associated herpesvirus regulates microRNA expression via its SH2-binding motif to induce cell migration and invasion

YH Tsai, MF Wu, YH Wu, SJ Chang, SF Lin… - Journal of …, 2009 - Am Soc Microbiol
Kaposi's sarcoma (KS) associated herpesvirus (KSHV) is the etiological agent of KS. In vivo,
KS is a tumor capable of spreading throughout the body, and pulmonary metastasis is …

Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCγ1 and activating NFAT1-dependent RCAN1 expression

K Bala, R Bosco, S Gramolelli, DA Haas, S Kati… - 2012 - journals.plos.org
Kaposi's Sarcoma (KS), caused by Kaposi's Sarcoma Herpesvirus (KSHV), is a highly
vascularised angiogenic tumor of endothelial cells, characterized by latently KSHV-infected …

NF-κB serves as a cellular sensor of Kaposi's sarcoma-associated herpesvirus latency and negatively regulates K-Rta by antagonizing the RBP-Jκ coactivator

Y Izumiya, C Izumiya, D Hsia, TJ Ellison… - Journal of …, 2009 - Am Soc Microbiol
Successful viral replication is dependent on a conducive cellular environment; thus, viruses
must be sensitive to the state of their host cells. We examined the idea that an interplay …

Inhibiting the recruitment of PLCγ1 to Kaposi's sarcoma herpesvirus K15 protein reduces the invasiveness and angiogenesis of infected endothelial cells

S Gramolelli, M Weidner-Glunde, B Abere… - PLoS …, 2015 - journals.plos.org
Kaposi's sarcoma (KS), caused by Kaposi's sarcoma herpesvirus (KSHV), is a highly
vascularised tumour of endothelial origin. KSHV infected endothelial cells show increased …