Impaired insulin signalling and allostatic load in Alzheimer disease
The discovery of insulin in 1921 revolutionized the treatment of diabetes and paved the way
for numerous studies on hormone signalling networks and actions in peripheral tissues and …
for numerous studies on hormone signalling networks and actions in peripheral tissues and …
The amyloid-β oligomer hypothesis: beginning of the third decade
The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …
Protein misfolding, amyloid formation, and human disease: a summary of progress over the last decade
Peptides and proteins have been found to possess an inherent tendency to convert from
their native functional states into intractable amyloid aggregates. This phenomenon is …
their native functional states into intractable amyloid aggregates. This phenomenon is …
Astrocyte heterogeneity: impact to brain aging and disease
I Matias, J Morgado, FCA Gomes - Frontiers in aging neuroscience, 2019 - frontiersin.org
Astrocytes, one of the largest glial cell population in the central nervous system (CNS), play
a key function in several events of brain development and function, such as synapse …
a key function in several events of brain development and function, such as synapse …
[HTML][HTML] Is Alzheimer's disease a type 3 diabetes? A critical appraisal
R Kandimalla, V Thirumala, PH Reddy - Biochimica et Biophysica Acta …, 2017 - Elsevier
Recently researchers proposed the term 'Type-3-Diabetes' for Alzheimer's disease (ad)
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2 …
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2 …
[HTML][HTML] The PI3K/Akt signaling axis in Alzheimer's disease: a valuable target to stimulate or suppress?
E Razani, A Pourbagheri-Sigaroodi… - Cell Stress and …, 2021 - Elsevier
Among the long list of age-related complications, Alzheimer's disease (AD) has the most
dreadful impact on the quality of life due to its devastating effects on memory and cognitive …
dreadful impact on the quality of life due to its devastating effects on memory and cognitive …
A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer's brain
It is increasingly accepted that early cognitive impairment in Alzheimer's disease results in
considerable part from synaptic dysfunction caused by the accumulation of a range of …
considerable part from synaptic dysfunction caused by the accumulation of a range of …
Endo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau missorting
MP Schützmann, F Hasecke, S Bachmann… - Nature …, 2021 - nature.com
Amyloid-β peptide (Aβ) forms metastable oligomers> 50 kDa, termed AβOs, that are more
effective than Aβ amyloid fibrils at triggering Alzheimer's disease-related processes such as …
effective than Aβ amyloid fibrils at triggering Alzheimer's disease-related processes such as …
Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis
Protein aggregation is common to dozens of diseases including prionoses, diabetes,
Parkinson's and Alzheimer's. Over the past 15 years, there has been a paradigm shift in …
Parkinson's and Alzheimer's. Over the past 15 years, there has been a paradigm shift in …
The mucosal immune system of teleost fish
I Salinas - Biology, 2015 - mdpi.com
Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …