Pre-eclampsia and fetal growth restriction arise from disorders of placental development and
have some shared mechanistic features. Initiation is often rooted in the maldevelopment of a …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Decidual artery remodeling is essential for a healthy pregnancy. This process involves loss
of vascular smooth muscle cells and endothelium, which are replaced by endovascular …

In human pregnancy, successful placentation and remodelling of the uterine vasculature
require the integration of a number of stages, which are crucial for a healthy pregnancy. As …

The cytokine tumour necrosis factor α (TNF) is a well known member of the TNF superfamily
consisting of at least 18 ligands and 29 different receptors involved in numerous cellular …

BACKGROUND During pregnancy, maternal uterine spiral arteries (SAs) are remodelled
from minimal-flow, high-resistance vessels into larger diameter vessels with low resistance …

Successful remodeling of the uterine spiral arteries is essential for a complication-free
pregnancy and is best described in terms of its morphologic features. The molecular …

The success of pregnancy is a result of countless ongoing interactions between the placenta
and the maternal immune and cardiovascular systems. Pre‐eclampsia is a serious …

Preeclampsia is a common and potentially lethal pregnancy complication for women and
offspring. Women who develop preeclampsia also run a long-term augmented risk of …

Cytokines in the reproductive tract environment at conception mediate a dialogue between
the embryo and maternal tissues to profoundly influence embryo development and …