Association between proton pump inhibitors and dementia risk: a Mendelian randomization study
K Xie, J Li, C Tang, Z Huang, M Chen - Scientific Reports, 2024 - nature.com
Numerous observational studies suggest associations between proton pump inhibitors
(PPIs) and dementia, but causal relationships remain uncertain. Using large-scale genome …
(PPIs) and dementia, but causal relationships remain uncertain. Using large-scale genome …
MR Corge: sensitivity analysis of Mendelian randomization based on the core gene hypothesis for polygenic exposures
Mendelian randomization is being utilized to assess causal effects of polygenic exposures,
where many genetic instruments are subject to horizontal pleiotropy. Existing methods for …
where many genetic instruments are subject to horizontal pleiotropy. Existing methods for …
Confounding Fuels Misinterpretation in Human Genetics
The scientific literature has seen a resurgence of interest in genetic influences on human
behavior and socioeconomic outcomes. Such studies face the central difficulty of …
behavior and socioeconomic outcomes. Such studies face the central difficulty of …
Low CD3 level is a risk factor for amyotrophic lateral sclerosis: a Mendelian randomization study
W Yang, X Liu, D Fan - Amyotrophic Lateral Sclerosis and …, 2024 - Taylor & Francis
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease characterized by
neuronal degeneration of the spinal cord and brain and believed to be related to the …
neuronal degeneration of the spinal cord and brain and believed to be related to the …
The Polygenic Score-Rare Variant Causal Pivot: A Conditional Approach to Discovery in Complex Disease Genetics
We present the Causal Pivot (CP) as a structural causal model (SCM) for analyzing genetic
heterogeneity in complex diseases. The CP leverages one established causal factor to …
heterogeneity in complex diseases. The CP leverages one established causal factor to …
Confounding Fuels Misinterpretation in Human Genetics
The scientific literature has seen a resurgence of interest in genetic influences on human
behavior and socioeconomic outcomes. Such studies face the central difficulty of …
behavior and socioeconomic outcomes. Such studies face the central difficulty of …
The breadth and impact of the Global Lipids Genetics Consortium
The GLGC has significantly advanced the understanding of the genetic basis of lipid levels
and serves as the leading resource of GWAS summary statistics for these traits. Continued …
and serves as the leading resource of GWAS summary statistics for these traits. Continued …