Recent advances in the treatment of sickle cell disease
G Salinas Cisneros, SL Thein - Frontiers in physiology, 2020 - frontiersin.org
Sickle cell anemia (SCA) was first described in the Western literature more than 100 years
ago. Elucidation of its molecular basis prompted numerous biochemical and genetic studies …
ago. Elucidation of its molecular basis prompted numerous biochemical and genetic studies …
Sickle cell disease
Sickle cell disease is caused by an alteration in a single DNA base, but its clinical
manifestations are influenced by other genes and behavioral and environmental factors …
manifestations are influenced by other genes and behavioral and environmental factors …
Global burden of sickle cell anaemia in children under five, 2010–2050: modelling based on demographics, excess mortality, and interventions
Background The global burden of sickle cell anaemia (SCA) is set to rise as a consequence
of improved survival in high-prevalence low-and middle-income countries and population …
of improved survival in high-prevalence low-and middle-income countries and population …
Hydroxyurea for children with sickle cell anemia in sub-Saharan Africa
L Tshilolo, G Tomlinson, TN Williams… - … England Journal of …, 2019 - Mass Medical Soc
Background Hydroxyurea is an effective treatment for sickle cell anemia, but few studies
have been conducted in sub-Saharan Africa, where the burden is greatest. Coexisting …
have been conducted in sub-Saharan Africa, where the burden is greatest. Coexisting …
Estimated life expectancy and income of patients with sickle cell disease compared with those without sickle cell disease
Importance Individuals with sickle cell disease (SCD) have reduced life expectancy;
however, there are limited data available on lifetime income in patients with SCD. Objective …
however, there are limited data available on lifetime income in patients with SCD. Objective …
Defining global strategies to improve outcomes in sickle cell disease: a Lancet Haematology Commission
Executive summary All over the world, people with sickle cell disease (an inherited
condition) have premature deaths and preventable severe chronic complications, which …
condition) have premature deaths and preventable severe chronic complications, which …
Population estimates of sickle cell disease in the US
KL Hassell - American journal of preventive medicine, 2010 - Elsevier
BACKGROUND: The number of individuals with sickle cell disease (SCD) in the US is
unknown. Determination of burden of disease, healthcare issues, and policies is best served …
unknown. Determination of burden of disease, healthcare issues, and policies is best served …
Improved survival of children and adolescents with sickle cell disease
CT Quinn, ZR Rogers, TL McCavit… - Blood, The Journal of …, 2010 - ashpublications.org
The survival of young children with sickle cell disease (SCD) has improved, but less is
known about older children and adolescents. We studied the Dallas Newborn Cohort (DNC) …
known about older children and adolescents. We studied the Dallas Newborn Cohort (DNC) …
Estimating the risk of child mortality attributable to sickle cell anaemia in sub-Saharan Africa: a retrospective, multicentre, case-control study
B Ranque, R Kitenge, DD Ndiaye, MD Ba… - The Lancet …, 2022 - thelancet.com
Background Many children with sickle cell disease living in sub-Saharan Africa die before
reaching age 5 years. We estimate the child mortality associated with sickle cell anaemia …
reaching age 5 years. We estimate the child mortality associated with sickle cell anaemia …
Sickle cell disease—genetics, pathophysiology, clinical presentation and treatment
Sickle cell disease (SCD) is a monogenetic disorder due to a single base-pair point mutation
in the β-globin gene resulting in the substitution of the amino acid valine for glutamic acid in …
in the β-globin gene resulting in the substitution of the amino acid valine for glutamic acid in …