Potential role of perivascular adipose tissue in modulating atherosclerosis

S Ahmadieh, HW Kim, NL Weintraub - Clinical Science, 2020 - portlandpress.com
Perivascular adipose tissue (PVAT) directly juxtaposes the vascular adventitia and contains
a distinct mixture of mature adipocytes, preadipocytes, stem cells, and inflammatory cells …

Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases

R Liu, CG Proud - Acta Pharmacologica Sinica, 2016 - nature.com
Eukaryotic elongation factor 2 kinase (eEF2K) is an unusual protein kinase that regulates
the elongation stage of protein synthesis by phosphorylating and inhibiting its only known …

The role of the FPR2/ALX receptor in atherosclerosis development and plaque stability

MH Petri, A Laguna-Fernandez… - Cardiovascular …, 2015 - academic.oup.com
Aims The formyl peptide receptor (FPR) subtype FPR2/ALX transduces pro-inflammatory
responses and participates in the resolution of inflammation depending on activation. The …

Two-faced Janus: the dual role of macrophages in atherosclerotic calcification

OJ Waring, NT Skenteris, EAL Biessen… - Cardiovascular …, 2022 - academic.oup.com
Calcification is an independent predictor of atherosclerosis-related cardiovascular events.
Microcalcification is linked to inflamed, unstable lesions, in comparison to the fibrotic stable …

Therapeutic potential of thymoquinone in triple-negative breast cancer prevention and progression through the modulation of the tumor microenvironment

GM Adinew, E Taka, B Mochona, RB Badisa… - Nutrients, 2021 - mdpi.com
To date, the tumor microenvironment (TME) has gained considerable attention in various
areas of cancer research due to its role in driving a loss of immune surveillance and …

Eukaryotic elongation factor-2 kinase (eEF2K) signaling in tumor and microenvironment as a novel molecular target

D Karakas, B Ozpolat - Journal of Molecular Medicine, 2020 - Springer
Eukaryotic elongation factor-2 kinase (eEF2K), an atypical member of alpha-kinase family, is
highly overexpressed in breast, pancreatic, brain, and lung cancers, and associated with …

Apigenin Attenuates Atherogenesis through Inducing Macrophage Apoptosis via Inhibition of AKT Ser473 Phosphorylation and Downregulation of Plasminogen …

P Zeng, B Liu, Q Wang, Q Fan, JX Diao… - Oxidative Medicine …, 2015 - Wiley Online Library
Macrophage survival is believed to be a contributing factor in the development of early
atherosclerotic lesions. Dysregulated apoptosis of macrophages is involved in the …

Oxysterols and mechanisms of survival signaling

B Vurusaner, G Leonarduzzi, P Gamba, G Poli… - Molecular Aspects of …, 2016 - Elsevier
Oxysterols, a family of oxidation products of cholesterol, are increasingly drawing attention of
scientists to their multifaceted biochemical properties, several of them of clear relevance to …

Control of CD4+ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase

HY Peng, L Wang, JK Das, A Kumar… - … and Targeted Therapy, 2023 - nature.com
Abstract CD4+ T cells, particularly IL-17-secreting helper CD4+ T cells, play a central role in
the inflammatory processes underlying autoimmune disorders. Eukaryotic Elongation Factor …

Heat-shock proteins in cardiovascular disease

J Madrigal-Matute, JL Martin-Ventura… - Advances in clinical …, 2011 - Elsevier
Heat-shock proteins (HSPs) belong to a group of highly conserved families of proteins
expressed by all cells and organisms and their expression may be constitutive or inducible …