Ischemic stroke is one of the leading causes of mortality and disability worldwide. However,
there is a current lack of effective therapies available. As the resident macrophages of the …

Aging can be seen as process characterized by accumulation of oxidative stress induced
damage. Oxidative stress derives from different endogenous and exogenous processes, all …

Background Accumulating evidence has shown that altered microRNA (miR) modulation is
implicated in the pathologies of ischemic stroke. However, it is unclear whether and how hsa …

Background Aging is a critical period of human life and paying attention to the needs and
diseases of this period is considered as a social necessity. One of the most neurological …

Incomplete recovery of blood–brain barrier (BBB) function contributes to stroke outcomes.
How the BBB recovers after stroke remains largely unknown. Emerging evidence suggests …

Hyperglycemia and inflammation, with their augmented interplay, are involved in cases of
stroke with poor outcomes. Interrupting this vicious cycle thus has the potential to prevent …

Objective Accumulated studies have explored gene polymorphisms and circulating levels of
tumor necrosis factor (TNF)-α and insulin-like growth factor (IGF)-1 in the etiology of …

Background The exploration of age-related clinical features and adverse outcomes of non-
disabling ischemic cerebrovascular disease (NICE) has been largely unaddressed in …

Cerebrovascular disease (CeVD) is a leading cause of death and disability worldwide. Early
detection of behavioral and physiologic changes associated with CeVD may be critical to …

Background: Oxidative stress-induced endothelial cell death, such as apoptosis and
autophagy, plays a critical role in ischemia-reperfusion injury. Protocatechualdehyde (PCA) …