Acute promyelocytic leukemia: a history over 60 years—from the most malignant to the most curable form of acute leukemia
X Thomas - Oncology and therapy, 2019 - Springer
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML)
that is cytogenetically characterized by a balanced reciprocal translocation between …
that is cytogenetically characterized by a balanced reciprocal translocation between …
Prognostic factors in acute promyelocytic leukemia: strategies to define high-risk patients
All trans retinoic acid (ATRA) has revolutionized the therapy of acute promyelocytic leukemia
(APL). Treatment of this leukemia with ATRA in combination with chemotherapy has resulted …
(APL). Treatment of this leukemia with ATRA in combination with chemotherapy has resulted …
The Impact of Flt3 Gene Mutations in Acute Promyelocytic Leukemia: A Meta-Analysis
GL Picharski, DP Andrade, ALMR Fabro, L Lenzi… - Cancers, 2019 - mdpi.com
The association of FLT3 mutations with white blood cell (WBC) counts at diagnosis and early
death was studied in patients with acute promyelocytic leukemia (APL). Publications …
death was studied in patients with acute promyelocytic leukemia (APL). Publications …
Characteristics and outcome of patients with core-binding factor acute myeloid leukemia and FLT3-ITD: results from an international collaborative study
S Kayser, M Kramer, D Martínez-Cuadrón… - …, 2021 - pmc.ncbi.nlm.nih.gov
The aim of this study was to evaluate the prognostic impact of FLT3-ITD in core-binding
factor acute myeloid leukemia (CBFAML) in an international, multicenter survey of 97 …
factor acute myeloid leukemia (CBFAML) in an international, multicenter survey of 97 …
FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias
C Esnault, R Rahmé, KL Rice, C Berthier… - Blood, The Journal …, 2019 - ashpublications.org
Acute promyelocytic leukemia (APL) is often associated with activating FLT3 signaling
mutations. These are highly related to hyperleukocytosis, a major adverse risk factor with …
mutations. These are highly related to hyperleukocytosis, a major adverse risk factor with …
Clinical networking results in continuous improvement of the outcome of patients with acute promyelocytic leukemia
LCA Koury, HT Kim, MS Undurraga… - Blood, 2024 - ashpublications.org
The introduction of all-trans retinoic acid combined with anthracyclines has significantly
improved the outcomes for patients diagnosed with acute promyelocytic leukemia (APL) …
improved the outcomes for patients diagnosed with acute promyelocytic leukemia (APL) …
Outcome of older (≥ 70 years) APL patients frontline treated with or without arsenic trioxide—an International Collaborative Study
S Kayser, R Rahmé, D Martínez-Cuadrón, G Ghiaur… - Leukemia, 2020 - nature.com
Data on outcome in older (≥ 70 years) patients with acute promyelocytic leukemia after
treatment with arsenic trioxide (ATO) compared with standard chemotherapy (CTX) is …
treatment with arsenic trioxide (ATO) compared with standard chemotherapy (CTX) is …
[HTML][HTML] Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide: an international collaborative …
S Kayser, RF Schlenk, D Lebon, M Carre… - …, 2021 - ncbi.nlm.nih.gov
The aim of this study was to characterize a large series of 154 patients with acute
promyelocytic leukemia (median age, 53 years; range, 18-90 years) and evaluate real-life …
promyelocytic leukemia (median age, 53 years; range, 18-90 years) and evaluate real-life …
Long‐term follow‐up of a phase 2 study of all‐trans retinoic acid, arsenic trioxide, and gemtuzumab ozogamicin in acute promyelocytic leukemia
WY Jen, J Marvin‐Peek, HM Kantarjian, Y Alvarado… - Cancer, 2024 - Wiley Online Library
Background All‐trans retinoic acid (ATRA) and arsenic trioxide (ATO) combinations have
produced excellent outcomes in patients with standard‐risk acute promyelocytic leukemia …
produced excellent outcomes in patients with standard‐risk acute promyelocytic leukemia …
[HTML][HTML] Recent advances in acute promyelocytic leukaemia
CH Ng, WJ Chng - F1000Research, 2017 - ncbi.nlm.nih.gov
Acute promyelocytic leukaemia (APML) is a subtype of leukaemia arising from a distinct
reciprocal translocation involving chromosomes 15 and 17, which results in the PML-RARA …
reciprocal translocation involving chromosomes 15 and 17, which results in the PML-RARA …