The precise temporal and spatial coordination of histone lysine methylation dynamics across
the epigenome regulates virtually all DNA-templated processes. A large number of histone …

The bromodomain (BrD) is a conserved structural module found in chromatin-and
transcription-associated proteins that acts as the primary reader for acetylated lysine …

BRD4 is well known for its role in super-enhancer organization and transcription activation
of several prominent oncogenes including c-MYC and BCL2. As such, BRD4 inhibitors are …

The BET (bromodomain and extra-terminal domain) family proteins, consisting of BRD2,
BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional …

As genomics advances reveal the cancer gene landscape, a daunting task is to understand
how these genes contribute to dysregulated oncogenic pathways. Integration of cancer …

The mammalian SWI/SNF chromatin remodeling complex is a heterogeneous collection of
related protein complexes required for gene regulation and genome integrity. It contains a …

Amplification of chromosomal region 8p11–12 is a common genetic alteration that has been
implicated in the aetiology of lung squamous cell carcinoma (LUSC),–. The FGFR1 gene is …

Higher-order chromatin structure regulates gene expression, and mutations in proteins
mediating genome folding underlie developmental disorders known as cohesinopathies …

Alterations of genes regulating epigenetic processes are frequently found as cancer drivers
and may cause widespread alterations of DNA methylation, histone modification patterns, or …

Targeting bromodomains (BRDs) of the bromo-and-extra-terminal (BET) family offers
opportunities for therapeutic intervention in cancer and other diseases. Here, we profile the …