Molecular mechanisms of leukocyte β2 integrin activation

L Wen, M Moser, K Ley - Blood, The Journal of the American …, 2022 - ashpublications.org
Integrins are transmembrane receptors that mediate cell-cell and cell-extracellular matrix
adhesion. Although all integrins can undergo activation (affinity change for ligands), the …

A guide to designing photocontrol in proteins: methods, strategies and applications

AC Kneuttinger - Biological Chemistry, 2022 - degruyter.com
Light is essential for various biochemical processes in all domains of life. In its presence
certain proteins inside a cell are excited, which either stimulates or inhibits subsequent …

Mechanobiological approaches to synthetic morphogenesis: learning by building

M Matejčić, X Trepat - Trends in Cell Biology, 2023 - cell.com
Tissue morphogenesis occurs in a complex physicochemical microenvironment with limited
experimental accessibility. This often prevents a clear identification of the processes that …

Direct binding of Rap1 to Talin1 and to MRL proteins promotes integrin activation in CD4+ T cells

F Lagarrigue, B Tan, Q Du, Z Fan… - The Journal of …, 2022 - journals.aai.org
Agonist-induced Rap1 GTP loading results in integrin activation involved in T cell trafficking
and functions. MRL proteins Rap1-interacting adapter molecule (RIAM) and lamellipodin …

Optogenetics and Its Transformative Role in Tissue Engineering and Regenerative Medicine

E Camcıoglu, DG Mohammadrezaloo, B Dinc - Nano Select, 2024 - Wiley Online Library
Optogenetics, a revolutionary technique leveraging light stimulation for precise cellular
control, holds immense potential in regenerative medicine. Offering unparalleled spatial and …

[HTML][HTML] 力调控Talin 与Rap1b 相互作用的分子动力学模拟

哲余, 彦儒姬, 文华黄, 颖方, 建华吴 - … Wu Yi Xue Gong Cheng Xue …, 2023 - ncbi.nlm.nih.gov
踝蛋白( Talin) 的F0 结构域与Ras 相关蛋白1b( Rap1b) 的结合对血栓形成至关重要。
然而Talin 作为一种力敏感蛋白, 力能否调控Talin-F0/Rap1b 的相互作用以及如何调控 …

Molecular dynamics simulation of force-regulated interaction between talin and Rap1b

Z Yu, Y Ji, W Huang, Y Fang, J Wu - Sheng wu yi xue Gong Cheng …, 2023 - europepmc.org
踝蛋白 (Talin) 的 F0 结构域与 Ras 相关蛋白 1b (Rap1b) 的结合对血栓形成至关重要. 然而
Talin 作为一种力敏感蛋白, 力能否调控 Talin-F0/Rap1b 的相互作用以及如何调控, 尚不明晰 …

The connection between Rap1 and Talin1 in CD4+ T Lymphocytes

F Lagarrigue, B Tan, Q Du, Z Fan, MA Lopez-Ramirez… - bioRxiv, 2021 - biorxiv.org
Agonist induced increase in integrin affinity for ligands (activation) plays a pivotal role in T
cell trafficking and functions. Activation requires Rap1 GTPase-mediated recruitment of …