Lysosomal nanotoxicity: Impact of nanomedicines on lysosomal function

M Uzhytchak, B Smolková, M Lunova, A Frtús… - Advanced Drug Delivery …, 2023 - Elsevier
Although several nanomedicines got clinical approval over the past two decades, the clinical
translation rate is relatively small so far. There are many post-surveillance withdrawals of …

Recent advances in amphotericin B delivery strategies for the treatment of leishmaniases

JS Lanza, S Pomel, PM Loiseau… - Expert opinion on drug …, 2019 - Taylor & Francis
Introduction: Among the drugs in clinical use for the treatment of leishmaniases,
amphotericin B (AmB) is the most effective and has been the most extensively studied for the …

Recent advances in chemotherapeutics for leishmaniasis: Importance of the cellular biochemistry of the parasite and its molecular interaction with the host

R Singh, M Kashif, P Srivastava, PP Manna - Pathogens, 2023 - mdpi.com
Leishmaniasis, a category 1 neglected protozoan disease caused by a kinetoplastid
pathogen called Leishmania, is transmitted through dipteran insect vectors (phlebotomine …

Innovating Leishmaniasis Treatment: A Critical Chemist's Review of Inorganic Nanomaterials

IAA Bessa, DL D'Amato, AB C. Souza… - ACS Infectious …, 2024 - ACS Publications
Leishmaniasis, a critical Neglected Tropical Disease caused by Leishmania protozoa,
represents a significant global health risk, particularly in resource-limited regions …

Nanotechnology-aided diagnosis, treatment and prevention of leishmaniasis

O Kammona, E Tsanaktsidou - International Journal of Pharmaceutics, 2021 - Elsevier
Leishmaniasis is a prevalent parasitic infection belonging to neglected tropical diseases. It is
caused by Leishmania protozoan parasites transmitted by sandflies and it is responsible for …

Nanoparticulate drug delivery systems for the treatment of neglected tropical protozoan diseases

G Volpedo, L Costa, N Ryan, G Halsey… - Journal of Venomous …, 2019 - SciELO Brasil
Abstract Neglected Tropical Diseases (NTDs) comprise of a group of seventeen infectious
conditions endemic in many developing countries. Among these diseases are three of …

Antiparasitic properties of propolis extracts and their compounds

LA de L. Paula, ACBB Cândido… - Chemistry & …, 2021 - Wiley Online Library
Propolis is a bee product that has been used in medicine since ancient times. Although its
anti‐inflammatory, antioxidant, antimicrobial, antitumor, and immunomodulatory activities …

Gallic and ellagic acids are promising adjuvants to conventional amphotericin B for the treatment of cutaneous leishmaniasis

MMM Alves, DDR Arcanjo, KA Figueiredo… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
In this study, we demonstrated the potential associative effect of combining conventional
amphotericin B (Amph B) with gallic acid (GA) and with ellagic acid (EA) in topical …

[HTML][HTML] A clioquinol-containing Pluronic® F127 polymeric micelle system is effective in the treatment of visceral leishmaniasis in a murine model

GSV Tavares, DVC Mendonça, IAG Pereira… - Parasite, 2020 - ncbi.nlm.nih.gov
A clioquinol (ICHQ)-containing Pluronic® F127 polymeric micelle system (ICHQ/Mic) was
recently shown to be effective against Leishmania amazonensis infection in a murine model …

Leishmanicidal therapy targeted to parasite proteases

P de Almeida Machado, MPD Carneiro… - Life sciences, 2019 - Elsevier
Leishmaniasis is considered a serious public health problem and the current available
therapy has several disadvantages, which makes the search for new therapeutic targets and …