Accurate DNA repair and replication are critical for genomic stability and cancer prevention.
RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double …

Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises
from the interaction of multiple factors including tobacco, alcohol consumption, and betel …

Aging is a leading risk factor for cancer. While it is proposed that age-related accumulation
of somatic mutations drives this relationship, it is likely not the full story. We show that aging …

Introduction Radiotherapy is a mainstay of cancer treatment. Clinical studies revealed a
heterogenous response to radiotherapy, from a complete response to even disease …

Simple Summary Glioblastoma stem cells (GBMSCs), which are particularly radio-resistant
and invasive, are responsible for the high recurrence of glioblastoma (GBM). Therefore …

Regulation of homologous recombination (HR) is central for cancer prevention. However,
too little HR can increase cancer incidence, whereas too much HR can drive cancer …

One major characteristic of tumor cells is the aberrant activation of epigenetic regulatory
elements, which remodel the tumor transcriptome and ultimately promote cancer …

During genome replication, replication forks often encounter obstacles that impede their
progression. Arrested forks are unstable structures that can give rise to collapse and …

Simple Summary Cells respond to genotoxic stress through complex protein pathways
called DNA damage response (DDR). These mechanisms ensure the preservation of …

Aim To study the role of EGFR signaling in regulation of intrinsic resistance in prostate
cancer. Materials and methods Radioresistant prostate carcinoma DU145 and PC-3 cells …