Neuromodulator and neuropeptide sensors and probes for precise circuit interrogation in vivo

J Muir, M Anguiano, CK Kim - Science, 2024 - science.org
To determine how neuronal circuits encode and drive behavior, it is often necessary to
measure and manipulate different aspects of neurochemical signaling in awake animals …

Cerebellar circuits for classical fear conditioning

KD Hwang, SJ Kim, YS Lee - Frontiers in cellular neuroscience, 2022 - frontiersin.org
Accumulating evidence indicates that the cerebellum is critically involved in modulating non-
motor behaviors, including cognition and emotional processing. Both imaging and lesion …

Norepinephrine release in the cerebellum contributes to aversive learning

AT Stanley, MR Post, C Lacefield, D Sulzer… - Nature …, 2023 - nature.com
The modulation of dopamine release from midbrain projections to the striatum has long
been demonstrated in reward-based learning, but the synaptic basis of aversive learning is …

Cerebellar-driven cortical dynamics can enable task acquisition, switching and consolidation

J Pemberton, P Chadderton, RP Costa - Nature Communications, 2024 - nature.com
The brain must maintain a stable world model while rapidly adapting to the environment, but
the underlying mechanisms are not known. Here, we posit that cortico-cerebellar loops play …

Probing the structure and function of locus coeruleus projections to CNS motor centers

BD Waterhouse, HK Predale, NW Plummer… - Frontiers in Neural …, 2022 - frontiersin.org
The brainstem nucleus locus coeruleus (LC) sends projections to the forebrain, brainstem,
cerebellum and spinal cord and is a source of the neurotransmitter norepinephrine (NE) in …

Inhibiting cholinergic signalling in the cerebellar interpositus nucleus impairs motor behaviour

J Pickford, CI Iosif, ZI Bashir… - European Journal of …, 2024 - Wiley Online Library
The role of neuromodulators in the cerebellum is not well understood. In particular, the
behavioural significance of the cholinergic system in the cerebellum is unknown. To …

Increased understanding of complex neuronal circuits in the cerebellar cortex

S Jun, H Park, M Kim, S Kang, T Kim, D Kim… - Frontiers in Cellular …, 2024 - frontiersin.org
The prevailing belief has been that the fundamental structures of cerebellar neuronal
circuits, consisting of a few major neuron types, are simple and well understood. Given that …

Topographic organization in the cerebellar nuclei and inferior olive in relation to cerebellar hemispheric lobules in the mouse: Distinction between crus I and …

RNA Owusu‐Mensah, GA Sarpong… - Journal of …, 2023 - Wiley Online Library
The parallel closed‐loop topographic connections between subareas of the inferior olive
(IO), cerebellar cortex, and cerebellar nuclei (CN) define the fundamental modular …

Activating lobule VI PCTH+–Med pathway in cerebellum blocks the acquisition of methamphetamine conditioned place preference in mice

F Ge, Z Wang, W Yu, X Yuan, Q Cai… - Journal of …, 2024 - Soc Neuroscience
Cerebellum has been implicated in drug addiction; however, its underlying cellular
populations and neuronal circuitry remain largely unknown. In the current study, we …

Dopaminergic regulation of vestibulo-cerebellar circuits through unipolar brush cells

JE Canton-Josh, J Qin, J Salvo, Y Kozorovitskiy - Elife, 2022 - elifesciences.org
While multiple monoamines modulate cerebellar output, the mechanistic details of
dopaminergic signaling in the cerebellum remain poorly understood. We show that …