[HTML][HTML] Targeting nerve growth factor for pain relief: pros and cons
S Jaffal, R Khalil - The Korean Journal of Pain, 2024 - synapse.koreamed.org
Nerve growth factor (NGF) is a neurotrophic protein that has crucial roles in survival, growth
and differentiation. It is expressed in neuronal and non-neuronal tissues. NGF exerts its …
and differentiation. It is expressed in neuronal and non-neuronal tissues. NGF exerts its …
An Engineered Bionic Nanoparticle Sponge as a Cytokine Trap and Reactive Oxygen Species Scavenger to Relieve Disc Degeneration and Discogenic Pain
W Yang, K Li, Q Pan, W Huang, Y Xiao, H Lin, S Liu… - ACS …, 2024 - ACS Publications
The progressive worsening of disc degeneration and related nonspecific back pain are
prominent clinical issues that cause a tremendous economic burden. Activation of reactive …
prominent clinical issues that cause a tremendous economic burden. Activation of reactive …
Persistent muscle hyperalgesia after adolescent stress is exacerbated by a mild-nociceptive input in adulthood and is associated with microglia activation
SK Singaravelu, AD Goitom, AP Graf, H Moerz… - Scientific reports, 2022 - nature.com
Non-specific low back pain (LBP) is a major global disease burden and childhood adversity
predisposes to its development. The mechanisms are largely unknown. Here, we …
predisposes to its development. The mechanisms are largely unknown. Here, we …
Inhibiting the JNK Signaling Pathway Attenuates Hypersensitivity and Anxiety-Like Behavior in a Rat Model of Non-specific Chronic Low Back Pain
Y Li, B Zhang, J Xu, X Jiang, L Jing, Y Tian… - Journal of Molecular …, 2024 - Springer
Low back pain (LBP) has become a leading cause of disability worldwide. Astrocyte
activation in the spinal cord plays an important role in the maintenance of latent sensitization …
activation in the spinal cord plays an important role in the maintenance of latent sensitization …
[HTML][HTML] Characterization of pain-related behaviors in a rat model of acute-to-chronic low back pain: single vs. multi-level disc injury
MF Barbe, FL Chen, RH Loomis, MY Harris… - Frontiers in Pain …, 2024 - ncbi.nlm.nih.gov
Methods Twenty-three Sprague-Dawley adult female rats were used: 8 received disc
puncture (DP) of one lumbar IVD (L5/6, DP-1); 8 received DP of two lumbar IVDs (L4/5 & …
puncture (DP) of one lumbar IVD (L5/6, DP-1); 8 received DP of two lumbar IVDs (L4/5 & …
Urokinase-type Plasminogen Activator-induced Mouse Back Pain Model
MA Montera, AE Goins, SRA Alles… - JoVE (Journal of …, 2023 - jove.com
A model of persisting lower back pain can be induced in mice with the simple methodology
described herein. Step-by-step methods for simple, rapid induction of a persisting back pain …
described herein. Step-by-step methods for simple, rapid induction of a persisting back pain …
Sex-related pain behavioral differences following unilateral NGF injections in a rat model of low back pain
M Syrett, NR Reed, WR Reed, ML Richey, A Frolov… - Biology, 2022 - mdpi.com
Simple Summary Low back pain (LBP) is a worldwide problem that requires additional
studies to better identify its underlying causes. One obstacle encountered is that female …
studies to better identify its underlying causes. One obstacle encountered is that female …
Timing matters: the impact of repeated restraint stress on NGF induced sensitization of spinal dorsal horn neurons in an animal model of myofascial low back pain.
SK Singaravelu - 2022 - archiv.ub.uni-heidelberg.de
Non-specific low back pain (nsLBP) is considered as the global leading cause of years lived
with disability affecting more than half a billion people. Adverse childhood experiences …
with disability affecting more than half a billion people. Adverse childhood experiences …
[PDF][PDF] Inhibiting the JNK Signaling Pathway Reverses Somatosensory Alterations and Anxiety-Like Behavior in a Non-Specific Chronic Low Back Pain Model
B Zhang, Y Li, W Shao, X Jiang, L Jing, Y Tian… - Available at SSRN … - papers.ssrn.com
Low back pain (LBP) has become a leading cause of disability worldwide. Previous studies
found that spinal c-Jun N-terminal kinase (JNK) participates in astrocyte activation in …
found that spinal c-Jun N-terminal kinase (JNK) participates in astrocyte activation in …
[引用][C] Sathish Kumar Singaravelu1Ε, Alexander Dawit Goitom1, Akseli Petteri Graf2
H Moerz, A Schilder, U Hoheisel, R Spanagel… - Scientific Reports, 2022