[HTML][HTML] The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment

EJ van Vuren, SF Steyn, CB Brink, M Möller… - Biomedicine & …, 2021 - Elsevier
The recent outbreak of the corona virus disease (COVID-19) has had major global impact.
The relationship between severe acute respiratory syndrome coronavirus (SARS-CoV-2) …

Translocator protein (18 kDa)(TSPO) as a therapeutic target for neurological and psychiatric disorders

R Rupprecht, V Papadopoulos, G Rammes… - Nature reviews Drug …, 2010 - nature.com
Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …

Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function

V Papadopoulos, M Baraldi, TR Guilarte… - Trends in …, 2006 - cell.com
The peripheral-type benzodiazepine receptor or recognition site (PBR) is a widely
distributed transmembrane protein that is located mainly in the outer mitochondrial …

Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans

DR Owen, N Narayan, L Wells… - Journal of Cerebral …, 2017 - journals.sagepub.com
The 18kDa Translocator Protein (TSPO) is the most commonly used tissue-specific marker of
inflammation in positron emission tomography (PET) studies. It is expressed in myeloid cells …

Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair

MK Chen, TR Guilarte - Pharmacology & therapeutics, 2008 - Elsevier
For over 15 years, the peripheral benzodiazepine receptor (PBR), recently named
translocator protein 18 kDa (TSPO) has been studied as a biomarker of reactive gliosis and …

Peripheral benzodiazepine receptors and mitochondrial function

P Casellas, S Galiegue, AS Basile - Neurochemistry international, 2002 - Elsevier
For over 20 years, numerous investigations have focused on elucidating the function of the
peripheral benzodiazepine receptor (PBR). This relatively small protein (18kDa) arouses …

Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response

L Veenman, V Papadopoulos… - Current pharmaceutical …, 2007 - ingentaconnect.com
Due to its channel-like properties, the peripheral-type benzodiazepine receptor (PBR) has
been renamed the translocator protein (TSPO). In eukaryotes, the TSPO is primarily located …

Hypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit

DF Kripke - F1000Research, 2018 - pmc.ncbi.nlm.nih.gov
This is a review of hypnotic drug risks and benefits. Almost every month, new information
appears about the risks of hypnotics (sleeping pills). The most important risks of hypnotics …

Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease

AM Barron, LM Garcia-Segura, D Caruso… - Journal of …, 2013 - Soc Neuroscience
Ligands of the translocator protein (TSPO) elicit pleiotropic neuroprotective effects that
represent emerging treatment strategies for several neurodegenerative conditions. To …

An FDA oncology analysis of toxicities associated with PBD-containing antibody-drug conjugates

H Saber, N Simpson, TK Ricks, JK Leighton - Regulatory Toxicology and …, 2019 - Elsevier
With a new generation of antibody-drug conjugates (ADCs) that contain a drug-to-antibody
ratio (DAR) of 2, the question remains whether advances in technology have resulted in …