Predictable cholesterol binding sites in GPCRs lack consensus motifs
A rich diversity of transmembrane G protein-coupled receptors (GPCRs) are used by
eukaryotes to sense physical and chemical signals. In humans alone, 800 GPCRs comprise …
eukaryotes to sense physical and chemical signals. In humans alone, 800 GPCRs comprise …
Substrate binding in the mitochondrial ADP/ATP carrier is a step-wise process guiding the structural changes in the transport cycle
V Mavridou, MS King, S Tavoulari, JJ Ruprecht… - Nature …, 2022 - nature.com
Mitochondrial ADP/ATP carriers import ADP into the mitochondrial matrix and export ATP to
the cytosol to fuel cellular processes. Structures of the inhibited cytoplasmic-and matrix-open …
the cytosol to fuel cellular processes. Structures of the inhibited cytoplasmic-and matrix-open …
How Fusarium graminearum GPCRs Contribute To Fungal Virulence On Wheat
PS Sridhar - 2023 - search.proquest.com
Fusarium graminearum is the principal causal agent of Fusarium Head Blight, one of the
most destructive diseases of wheat. Infection of wheat by F. graminearum results in …
most destructive diseases of wheat. Infection of wheat by F. graminearum results in …
Probing drug-target engagement of soluble Gαi1 protein using the SolThermoBRET thermal shift assay
O Brod, D Plevako, T Perera, P Hompluem, EJ Koers… - bioRxiv, 2024 - biorxiv.org
Introduction: Sensitive protein stability assays used during hit confirmation conventionally
require high quantities of purified protein. Here, we describe a novel high-throughput 384 …
require high quantities of purified protein. Here, we describe a novel high-throughput 384 …
ThermoFRET: A novel nanoscale G protein coupled receptor thermostability assay functional in crude solubilised membrane preparations
Sensitive protein stability assays for membrane proteins are crucial for developing
purification protocols, for structural and biophysical characterisation and drug discovery …
purification protocols, for structural and biophysical characterisation and drug discovery …
[PDF][PDF] Cellular and Computational Studies of G Protein-coupled Receptor Structure, Function, and Ligand Binding
GJF Taghon - scholarship.miami.edu
Though the human G protein-coupled receptor (GPCR) superfamily is a pillar of
pharmaceutical treatment, hundreds of GPCRs have yet unknown roles and are difficult to …
pharmaceutical treatment, hundreds of GPCRs have yet unknown roles and are difficult to …