Advances in bladder cancer biology and therapy

L Tran, JF Xiao, N Agarwal, JE Duex… - Nature Reviews …, 2021 - nature.com
The field of research in bladder cancer has seen significant advances in recent years. Next-
generation sequencing has identified the genes most mutated in bladder cancer. This …

TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K/AKT pathway in bladder cancer

M Chi, J Liu, C Mei, Y Shi, N Liu, X Jiang, C Liu… - Journal of Experimental …, 2022 - Springer
Background The distant metastasis is the primary cause of cancer morbidity and mortality for
bladder cancer (BLCA) paitents. All the recommended therapy for it largely depends on how …

FOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the …

CC Sun, W Zhu, SJ Li, W Hu, J Zhang, Y Zhuo… - Genome medicine, 2020 - Springer
Abstract Background Long non-coding RNAs (lncRNAs) are extensively intricate in the
tumorigenesis and metastasis of various cancer types. Nevertheless, the detailed molecular …

Impact of molecular subtyping and immune infiltration on pathological response and outcome following neoadjuvant pembrolizumab in muscle-invasive bladder …

A Necchi, D Raggi, A Gallina, JS Ross, E Farè… - European urology, 2020 - Elsevier
Abstract Background The PURE-01 study (NCT02736266) evaluated the use of
pembrolizumab before radical cystectomy (RC) in muscle-invasive bladder cancer (MIBC) …

Identifying novel biomarkers associated with bladder cancer treatment outcomes

PR Castaneda, D Theodorescu, CJ Rosser… - Frontiers in …, 2023 - frontiersin.org
Bladder cancer is a complex disease with variable prognosis. Recent investigations into the
molecular landscape of bladder cancer have revealed frequent genetic alterations and …

Comprehensive analysis of scRNA-Seq and bulk RNA-Seq reveals dynamic changes in the tumor immune microenvironment of bladder cancer and establishes a …

Z Tan, X Chen, J Zuo, S Fu, H Wang, J Wang - Journal of translational …, 2023 - Springer
Background The prognostic management of bladder cancer (BLCA) remains a great
challenge for clinicians. Recently, bulk RNA-seq sequencing data have been used as a …

Non–muscle-invasive bladder cancer molecular subtypes predict differential response to intravesical Bacillus Calmette-Guérin

FC de Jong, TD Laajala, RF Hoedemaeker… - Science translational …, 2023 - science.org
The recommended treatment for patients with high-risk non–muscle-invasive bladder cancer
(HR-NMIBC) is tumor resection followed by adjuvant Bacillus Calmette-Guérin (BCG) …

Genomic tumor correlates of clinical outcomes following organ-sparing chemoradiation therapy for bladder cancer

SC Kamran, Y Zhou, K Otani, M Drumm, Y Otani… - Clinical Cancer …, 2023 - AACR
Purpose: There is an urgent need for biomarkers of radiation response in organ-sparing
therapies. Bladder preservation with trimodality therapy (TMT), consisting of transurethral …

Glycolysis-associated lncRNAs identify a subgroup of cancer patients with poor prognoses and a high-infiltration immune microenvironment

KH Ho, TW Huang, CM Shih, YT Lee, AJ Liu, PH Chen… - BMC medicine, 2021 - Springer
Abstract Background Long noncoding (lnc) RNAs and glycolysis are both recognized as key
regulators of cancers. Some lncRNAs are also reportedly involved in regulating glycolysis …

Non-muscle-invasive micropapillary bladder cancer has a distinct lncRNA profile associated with unfavorable prognosis

JJ de Jong, BP Valderrama, J Perera… - British Journal of …, 2022 - nature.com
Background Molecular subtyping of bladder cancer has revealed luminal tumors generally
have a more favourable prognosis. However, some aggressive forms of variant histology …