In comparison with 2D cell culture models, 3D spheroids are able to accurately mimic some
features of solid tumors, such as their spatial architecture, physiological responses …

Cancer immunotherapy is the great breakthrough in cancer treatment as it displayed
prolonged progression-free survival over conventional therapies, yet, to date, in only a …

Cholangiocarcinoma (CCA) is a rare, aggressive disease with poor overall survival. In
advanced cases, surgery is often not possible or fails; in addition, there is a lack of effective …

Cholangiopathies, such as primary sclerosing cholangitis, biliary atresia, and
cholangiocarcinoma, have limited experimental models. Not only cholangiocytes but also …

The liver is the most important metabolic hub of endo and xenobiotic compounds. Pre-
clinical studies using rodents to evaluate the toxicity of new drugs and cosmetics may …

Human cholangiocarcinoma (CCA) is an aggressive tumour entity arising from the biliary
tree, whose molecular pathogenesis remains largely undeciphered. Over the last decade …

Hypoxia in solid tumors remains a challenge for conventional cancer therapeutics. As a
source for resistance, metastasis development and drug bioprocessing, it influences …

Introduction: Cholangiocarcinoma (CCA) is a devastating liver tumor with a poor prognosis.
While less than 50% of the patients with CCA may benefit from surgical resection, the rest …

Primary sclerosing cholangitis (PSC) is an autoimmune cholangiopathy characterized by
chronic inflammation of the biliary epithelium and periductal fibrosis, with no curative …

Uterine leiomyomas are monoclonal tumors. Several factors are involved in the neoplastic
transformation of the myometrium. In our study we focused on dysregulated cytoskeletal …