N Manduca, E Maccafeo, R De Maria, A Sistigu… - Frontiers in …, 2023 - frontiersin.org
Cancer immunotherapy is the great breakthrough in cancer treatment as it displayed prolonged progression-free survival over conventional therapies, yet, to date, in only a …
A Massa, C Varamo, F Vita, S Tavolari, C Peraldo-Neia… - Cancers, 2020 - mdpi.com
Cholangiocarcinoma (CCA) is a rare, aggressive disease with poor overall survival. In advanced cases, surgery is often not possible or fails; in addition, there is a lack of effective …
K Sato, W Zhang, S Safarikia, A Isidan, AM Chen… - …, 2021 - Wiley Online Library
Cholangiopathies, such as primary sclerosing cholangitis, biliary atresia, and cholangiocarcinoma, have limited experimental models. Not only cholangiocytes but also …
The liver is the most important metabolic hub of endo and xenobiotic compounds. Pre- clinical studies using rodents to evaluate the toxicity of new drugs and cosmetics may …
Human cholangiocarcinoma (CCA) is an aggressive tumour entity arising from the biliary tree, whose molecular pathogenesis remains largely undeciphered. Over the last decade …
E Schreiber-Brynzak, V Pichler, P Heffeter… - Metallomics, 2016 - academic.oup.com
Hypoxia in solid tumors remains a challenge for conventional cancer therapeutics. As a source for resistance, metastasis development and drug bioprocessing, it influences …
L Baiocchi, K Sato, B Ekser, L Kennedy… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: Cholangiocarcinoma (CCA) is a devastating liver tumor with a poor prognosis. While less than 50% of the patients with CCA may benefit from surgical resection, the rest …
W Chen, F Lin, X Feng, Q Yao, Y Yu, F Gao… - Asian Journal of …, 2024 - Elsevier
Primary sclerosing cholangitis (PSC) is an autoimmune cholangiopathy characterized by chronic inflammation of the biliary epithelium and periductal fibrosis, with no curative …
B Ura, F Scrimin, G Arrigoni… - Oncology …, 2016 - spandidos-publications.com
Uterine leiomyomas are monoclonal tumors. Several factors are involved in the neoplastic transformation of the myometrium. In our study we focused on dysregulated cytoskeletal …