Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours

C Horbinski, T Berger, RJ Packer, PY Wen - Nature Reviews Neurology, 2022 - nature.com
A new edition of the WHO classification of tumours of the CNS was published in 2021.
Although the previous edition of this classification was published just 5 years earlier, in …

Prognostic and predictive biomarkers in gliomas

P Śledzińska, MG Bebyn, J Furtak… - International journal of …, 2021 - mdpi.com
Gliomas are the most common central nervous system tumors. New technologies, including
genetic research and advanced statistical methods, revolutionize the therapeutic approach …

Sarcoma classification by DNA methylation profiling

C Koelsche, D Schrimpf, D Stichel, M Sill… - Nature …, 2021 - nature.com
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and
children. They represent a morphologically heterogeneous class of tumours and some …

Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

D Sturm, D Capper, F Andreiuolo, M Gessi… - Nature medicine, 2023 - nature.com
The large diversity of central nervous system (CNS) tumor types in children and adolescents
results in disparate patient outcomes and renders accurate diagnosis challenging. In this …

cIMPACT‐NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT‐Utrecht meeting on future CNS tumor classification and grading

DN Louis, P Wesseling, K Aldape, DJ Brat, D Capper… - 2020 - Wiley Online Library
Abstract cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to
CNS Tumor Taxonomy) was established to evaluate and make practical recommendations …

A summary of the inaugural WHO classification of pediatric tumors: transitioning from the optical into the molecular era

SM Pfister, M Reyes-Múgica, JKC Chan, H Hasle… - Cancer discovery, 2022 - AACR
Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in
childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often …

Primary brain tumours in adults

MJ van den Bent, M Geurts, PJ French, M Smits… - The Lancet, 2023 - thelancet.com
The most frequent adult-type primary CNS tumours are diffuse gliomas, but a large variety of
rarer CNS tumour types exists. The classification of these tumours is increasingly based on …

The 2021 WHO classification of tumors of the central nervous system: an update on pediatric low‐grade gliomas and glioneuronal tumors

TA Bale, MK Rosenblum - Brain Pathology, 2022 - Wiley Online Library
The 2021 5th edition of the WHO Classification of Tumors of the Central Nervous System
reflects the discovery of genetic alterations underlying many central nervous system (CNS) …

cIMPACT-NOW update 3: recommended diagnostic criteria for “Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV”

DJ Brat, K Aldape, H Colman, EC Holland… - Acta …, 2018 - Springer
The World Health Organization (WHO) central nervous system tumor classification
represents the primary source of updates on diagnostic classes, grades and criteria [17] …

The 2021 WHO classification of tumors of the central nervous system: clinical implications

PY Wen, RJ Packer - Neuro-oncology, 2021 - academic.oup.com
The fifth edition of the World Health Organization (WHO) Classification of Tumors of the
Central Nervous System (CNS)(WHO CNS5) was recently released and summarized by …