Blood viscosity is an important determinant of local flow characteristics, which exhibits shear
thinning behavior: it decreases exponentially with increasing shear rates. Both hematocrit …

Human red blood cells (RBC) are highly differentiated cells that have lost all organelles and
most intracellular machineries during their maturation process. RBC are fundamental for the …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

Sickle cell disease (SCD) is a recessive genetic blood disorder exhibiting abnormal blood
rheology. Polymerization of sickle hemoglobin, due to a point mutation in the β‐globin gene …

Sickle cell disease (SCD) afflicts millions of people worldwide and is associated with
considerable morbidity and mortality. Chronic and acute vaso-occlusion are the clinical …

Polycythemia vera (PV) is characterized by an increased RBC mass, spontaneous erythroid
colony formation, and the JAK2V617F mutation. PV is associated with a high risk of …

Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by chronic
anemia, intravascular hemolysis, and the occurrence of vaso-occlusive crises due to the …

Red blood cell (RBC) adhesion to endothelium can be studied in static and flow conditions.
Increased RBC adhesion was first described in sickle cell disease. Several molecules were …

Sickle cell disease (SCD), which afflicts 100 000 Americans, as well as millions worldwide,
is associated with anemia, lifelong morbidity, and early mortality. Abnormal adhesion of …

Background: Retinal vein occlusion (RVO) is a common cause of permanent loss of vision.
The pathophysiology is uncertain, although enhanced erythrocyte aggregation and blood …