KIR receptors as key regulators of NK cells activity in health and disease
J Dębska-Zielkowska, G Moszkowska, M Zieliński… - Cells, 2021 - mdpi.com
Natural killer (NK) cells are part of the cellular immune response. They target mainly cancer
and virally infected cells. To a high extent cytotoxic activity of NK cells is regulated inter alia …
and virally infected cells. To a high extent cytotoxic activity of NK cells is regulated inter alia …
IL28B, HLA-C, and KIR Variants Additively Predict Response to Therapy in Chronic Hepatitis C Virus Infection in a European Cohort: A Cross-Sectional Study
V Suppiah, S Gaudieri, NJ Armstrong… - PLoS …, 2011 - journals.plos.org
Background To date, drug response genes have not proved as useful in clinical practice as
was anticipated at the start of the genomic era. An exception is in the treatment of chronic …
was anticipated at the start of the genomic era. An exception is in the treatment of chronic …
Allele-Level KIR Genotyping of More Than a Million Samples: Workflow, Algorithm, and Observations
I Wagner, D Schefzyk, J Pruschke, G Schöfl… - Frontiers in …, 2018 - frontiersin.org
The killer-cell immunoglobulin-like receptor (KIR) genes regulate natural killer cell activity,
influencing predisposition to immune mediated disease, and affecting hematopoietic stem …
influencing predisposition to immune mediated disease, and affecting hematopoietic stem …
KIR gene content diversity in four Iranian populations
Killer cell immunoglobulin-like receptors (KIR) regulate natural killer cell response against
infection and malignancy. KIR genes are variable in the number and type, thereby …
infection and malignancy. KIR genes are variable in the number and type, thereby …
KIR and HLA genotypes predictive of low-affinity interactions are associated with lower relapse in autologous hematopoietic cell transplantation for acute myeloid …
J Marra, J Greene, J Hwang, J Du, L Damon… - The Journal of …, 2015 - journals.aai.org
Killer cell Ig–like receptors (KIRs) bind cognate HLA class I ligands with distinct affinities,
affecting NK cell licensing and inhibition. We hypothesized that differences in KIR and HLA …
affecting NK cell licensing and inhibition. We hypothesized that differences in KIR and HLA …
[HTML][HTML] No impact of KIR-ligand mismatch on allograft outcome in HLA-compatible kidney transplantation
TH Tran, C Unterrainer, G Fiedler, B Döhler… - American Journal of …, 2013 - Elsevier
Natural killer (NK) cell function can be modulated by the killer cell immunoglobulin-like
receptors (KIR) which interact with human leukocyte antigen (HLA) class I molecules on …
receptors (KIR) which interact with human leukocyte antigen (HLA) class I molecules on …
Coexistence of inhibitory and activating killer-cell immunoglobulin-like receptors to the same cognate HLA-C2 and Bw4 ligands confer breast cancer risk
Human leukocyte antigen (HLA) class I-specific killer-cell immunoglobulin-like receptors
(KIR) regulate natural killer (NK) cell function in eliminating malignancy. Breast cancer (BC) …
(KIR) regulate natural killer (NK) cell function in eliminating malignancy. Breast cancer (BC) …
KIR2DS1, 2DS5, 3DS1 and KIR2DL5 are associated with the risk of head and neck squamous cell carcinoma in Iranians
Background Activating and inhibitory KIR receptors (aKIR, iKIR) control the development
and function of NK cells whose function alterations adjust the tumor microenvironment …
and function of NK cells whose function alterations adjust the tumor microenvironment …
Development of cost‐effective and fast KIR genotyping by multiplex PCR‐SSP
EJ Choi, IC Baek, S Park, HJ Kim, TG Kim - Hla, 2024 - Wiley Online Library
Killer‐cell immunoglobulin‐like receptors (KIR) control natural killer (NK) cell functions by
recognizing HLA molecules and modulating the activity of NK cells. The KIR gene cluster …
recognizing HLA molecules and modulating the activity of NK cells. The KIR gene cluster …
Activating and inhibitory killer cell immunoglobulin like receptors (KIR) genes are involved in an increased susceptibility to colorectal adenocarcinoma and protection …
Background: A set of activating and inhibitory KIRs (aKIR, iKIR) are involved in NK cell
mediated immunity. This study was carried out in order to investigate the KIRs pattern and its …
mediated immunity. This study was carried out in order to investigate the KIRs pattern and its …