With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

Axonal demyelination is a consistent pathological characteristic of Spinal cord injury (SCI).
Promoting differentiation of oligodendrocytes is of importance for remyelination. Conversion …

In this study, we investigated the effect of neuregulin-1 (NRG1) on demyelination and
neurological function in an ischemic stroke model, and further explored its neuroprotective …

Background Human cerebral malaria (HCM) is a severe form of malaria characterized by
sequestration of infected erythrocytes (IRBCs) in brain microvessels, increased levels of …

Ginsenoside Rd (Rd), one of the main active ingredients in Panax ginseng, has been
showed to protect against ischemic cerebral damage both in vitro and in vivo. However, the …

Cervical spinal cord injury (SCI) damages axons and motor neurons responsible for
ipsilateral forelimb function and causes demyelination and oligodendrocyte death. Inhibition …

Alzheimer's disease (AD) is characterized by the deposition of beta-amyloid protein (Aβ) and
extensive neuronal cell death. Apoptosis plays a crucial role in loss of neurons in AD …

Neuregulin-1 (NRG1) is a growth factor that belongs to a family of polypeptide growth factors
encoded by four neuregulin genes. NRG1 signals are transduced through the ErbB family of …

Hypoxic-ischemia (HI) not only causes gray matter injury but also white matter injury, leading
to severe neurological deficits and mortality, and only limited therapies exist. The white …

Oligodendrocytes are the cells producing the myelin membrane around the axons in the
central nervous system and, although apotransferrin (aTf) is required for oligodendrocyte …