Glycans, carbohydrate molecules in the realm of biology, are present as biomedically
important glycoconjugates and a characteristic aspect is that their structures in many …

Mycobacterium tuberculosis remains one of the most successful bacterial pathogens,
claiming over 1.3 million lives worldwide in 2013. The emergence of multidrug-resistant and …

Most diagnostic tests for tuberculosis (TB) rely on sputum samples, which are difficult to
obtain and have low sensitivity in immunocompromised patients, patients with disseminated …

Approximately one third of the world's population is infected with Mycobacterium
tuberculosis, the causative agent of tuberculosis. This bacterium has an unusual lipid-rich …

BACKGROUND Inadequate tuberculosis (TB) diagnostics are a major hurdle in the
reduction of disease burden, and accurate point-of-care tests (POCTs) are urgently needed …

The re-emergence of tuberculosis in its present-day manifestations–single, multiple and
extensive drug-resistant forms and as HIV-TB coinfections–has resulted in renewed …

Tuberculosis (TB) remains the second most common cause of death due to a single
infectious agent. The cell envelope of Mycobacterium tuberculosis (Mtb), the causative agent …

The only currently commercialized point-of-care assay for tuberculosis (TB) that measures
lipoarabinomannan (LAM) in urine (Alere LF-LAM) has insufficient sensitivity. We evaluated …

We report a new method for stereoselective O-furanosylation reactions promoted by a
precisely tailored bis-thiourea hydrogen-bond-donor catalyst. Furanosyl donors outfitted with …

Oligosaccharides are the ubiquitous molecules of life. In order to translate human
bioglycosylation into clinical applications, homogeneous samples of oligosaccharides and …