During morphogenesis, changes in the shapes of individual cells are harnessed to mold an
entire tissue. These changes in cell shapes require the coupled remodeling of the plasma …

Epidermal growth factor receptor (EGFR) and adhesion protein E-cadherin are major
regulators of proliferation and differentiation in epithelial cells. Consistently, defects in both …

Transverse (T)-tubules make-up a specialized network of tubulated muscle cell membranes
involved in excitation-contraction coupling for power of contraction. Little is known about …

The actin cytoskeleton plays crucial roles in many cellular processes, including regulated
secretion. However, the mechanisms controlling F-actin dynamics in this process are largely …

Clathrin-mediated endocytosis is the main entry route for most cell surface receptors and
their ligands. It is regulated by clathrin-coated structures that are endowed with the ability to …

Underlying the plasma membrane of eukaryotic cells is an actin cortex that includes actin
filaments and associated proteins. A special feature of all polarized and epithelial cells are …

Podosomes represent a class of integrin-mediated cell-matrix adhesions formed by
migrating and matrix-degrading cells. We demonstrate that in macrophage-like THP1 cells …

Adherens junctions provide attachments between neighboring epithelial cells and a physical
link to the cytoskeleton, which enables them to sense and transmit forces and to initiate …

Cadherin‐based adherens junctions are critical for connecting cells in tissues. Regulated
cadherin trafficking also makes these complexes amazingly dynamic, with permissive and …

In response to a pulling force, a material can elongate, hold fast, or fracture. During animal
development, multi-cellular contraction of one region often stretches neighboring tissue …