Lung cancer has the highest mortality rate of all cancers worldwide. Lung cancer is a very
heterogeneous disease that is often diagnosed at later stages which have a poor prognosis …

Splicing is a critical processing step during pre-mRNA maturation in eukaryotes. The correct
selection of splice sites during the early steps of spliceosome assembly is highly important …

Structural resolution of protein interactions enables mechanistic and functional studies as
well as interpretation of disease variants. However, structural data is still missing for most …

RNA-binding proteins (RBPs) are key players regulating RNA processing and are
associated with disorders ranging from cancer to neurodegeneration. Here, we present a …

The RNA-binding motif protein RBM5 belongs to a family of multi-domain RNA binding
proteins that regulate alternative splicing of genes important for apoptosis and cell …

Understanding the mechanisms of pre-mRNA splicing is limited by the technical challenges
to examining spliceosomes in vivo. Here, we report the isolation of RNP complexes derived …

RBM10 is a nuclear RNA-binding protein (RBP) that regulates the alternative splicing of
primary transcripts. Recently, research on RBM10 has become increasingly active owing to …

Infertility is rarely life threatening, however, it poses a serious global health issue posing far-
reaching socio-economic impacts affecting 12–15% of couples worldwide where male factor …

Interactions between U2AF homology motifs (UHMs) and U2AF ligand motifs (ULMs) play a
crucial role in early spliceosome assembly in eukaryotic gene regulation. UHM-ULM …

RNA-binding proteins regulate mRNA processing and translation and are often aberrantly
expressed in cancer. The RNA-binding motif protein 6, RBM6, is a known alternative splicing …