Idiosyncratic drug reactions (IDRs) range from relatively common, mild reactions to rarer,
potentially life-threatening adverse effects that pose significant risks to both human health …

Acetaminophen (APAP) hepatotoxicity is an important cause of acute liver failure, resulting
in massive deaths in many developed countries. Currently, the metabolic process of APAP in …

MicroRNAs (miRNA) are closely associated with the development of diseases in life
processes, and the sensitive detection of microRNA biomarkers is beneficial to disease …

Drug-induced liver injury (DILI) is one of the major causes of post-approval withdrawal of
therapeutics. As a result, there is an increasing need for accurate predictive in vitro assays …

When Larry Marnett founded Chemical Research in Toxicology, the study of idiosyncratic
drug reactions (IDRs) was in its infancy. There was evidence that IDRs involve chemically …

Abstract Ethnopharmacological relevance Perilla Folium (PF), is a traditional medicinal
material with the homology of medicine and food in China and has been widely used due to …

Objective: Polygonum multiflorum Thunb.(PM) is a commonly used tonic herb known to
cause idiosyncratic drug-induced liver injury (IDILI). This study explored the detoxification …

Drug-induced liver injury (DILI) is a major contributor to high attrition rates among candidate
and market drugs and a key regulatory, industry, and global health concern. While acute and …

Geniposide, the main active component of Fructus Gardeniae (FG), is known to confer
protection against liver diseases. Herein we explored the hepatoprotective effects of …

Results: Most studies have reported the effects of hepatotoxicity by azole antifungal agents,
and their mechanisms have been described. Conclusions: Clinical evaluations regarding …