Neurovascular dysfunction in glaucoma

L Alarcon-Martinez, Y Shiga… - Progress in Retinal and …, 2023 - Elsevier
Retinal ganglion cells, the neurons that die in glaucoma, are endowed with a high
metabolism requiring optimal provision of oxygen and nutrients to sustain their activity. The …

Upregulating human cathelicidin antimicrobial peptide LL-37 expression may prevent severe COVID-19 inflammatory responses and reduce microthrombosis

KM Aloul, JE Nielsen, EB Defensor, JS Lin… - Frontiers in …, 2022 - frontiersin.org
COVID-19 is characterized by hyperactivation by inflammatory cytokines and recruitment of
macrophages, neutrophils, and other immune cells, all hallmarks of a strong inflammatory …

Hippocampal subfield abnormalities and biomarkers of pathologic brain changes: from SARS-CoV-2 acute infection to post-COVID syndrome

M Díez-Cirarda, M Yus-Fuertes, R Sanchez-Sanchez… - …, 2023 - thelancet.com
Background Cognitive deficits are among the main disabling symptoms in COVID-19
patients and post-COVID syndrome (PCS). Within brain regions, the hippocampus, a key …

[HTML][HTML] SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein

R Khaddaj-Mallat, N Aldib, M Bernard… - Neurobiology of …, 2021 - Elsevier
Abstract Coronavirus disease 19 (COVID-19) is a respiratory illness caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2). COVID-19 pathogenesis causes …

SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier

C Stüdle, H Nishihara, S Wischnewski… - Fluids and Barriers of …, 2023 - Springer
Background As a consequence of SARS-CoV-2 infection various neurocognitive and
neuropsychiatric symptoms can appear, which may persist for several months post infection …

Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vaping

Y Zhang, SR Archie, Y Ghanwatkar, S Sharma… - Fluids and Barriers of …, 2022 - Springer
Background Knowledge of the entry receptors responsible for SARS-CoV-2 is key to
understand the neural transmission and pathogenesis of COVID-19 characterized by a …

Central nervous system pericytes contribute to health and disease

F Girolamo, M Errede, A Bizzoca, D Virgintino, D Ribatti - Cells, 2022 - mdpi.com
Successful neuroprotection is only possible with contemporary microvascular protection.
The prevention of disease-induced vascular modifications that accelerate brain damage …

Mechanism of COVID-19-induced cardiac damage from patient, in vitro and animal studies

EAV Jones - Current Heart Failure Reports, 2023 - Springer
Abstract Purpose of Review Though patient studies have been important for understanding
the disease, research done in animals and cell culture complement our knowledge from …

A tight squeeze: how do we make sense of small changes in microvascular diameter?

H Davis, D Attwell - The Journal of physiology, 2023 - Wiley Online Library
The brain is an energetically demanding tissue which, to function adequately, requires
constant fine tuning of its supporting blood flow, and hence energy supply. Whilst blood flow …

SARS-CoV-2 RNA in the cerebrospinal fluid of a patient with long COVID

D Viszlayová, M Sojka… - Therapeutic …, 2021 - journals.sagepub.com
Over 10% of COVID-19 convalescents report post-COVID-19 complications, namely,'long
COVID'or 'post-COVID syndrome,'including a number of neuro-psychiatric symptoms. The …