[HTML][HTML] Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses
C Wallace - PLoS genetics, 2020 - journals.plos.org
Horizontal integration of summary statistics from different GWAS traits can be used to
evaluate evidence for their shared genetic causality. One popular method to do this is a …
evaluate evidence for their shared genetic causality. One popular method to do this is a …
Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associations
Brain imaging can be used to study how individuals' brains are aging, compared against
population norms. This can inform on aspects of brain health; for example, smoking and …
population norms. This can inform on aspects of brain health; for example, smoking and …
[HTML][HTML] rs1990622 variant associates with Alzheimer's disease and regulates TMEM106B expression in human brain tissues
Y Hu, J Sun, Y Zhang, H Zhang, S Gao, T Wang, Z Han… - BMC medicine, 2021 - Springer
Background It has been well established that the TMEM106B gene rs1990622 variant was a
frontotemporal dementia (FTD) risk factor. Until recently, growing evidence highlights the …
frontotemporal dementia (FTD) risk factor. Until recently, growing evidence highlights the …
Genome-wide landscape of RNA-binding protein target site dysregulation reveals a major impact on psychiatric disorder risk
Despite the strong genetic basis of psychiatric disorders, the underlying molecular
mechanisms are largely unmapped. RNA-binding proteins (RBPs) are responsible for most …
mechanisms are largely unmapped. RNA-binding proteins (RBPs) are responsible for most …
From Mouse to Man: N-Methyl-d-Aspartic Acid Receptor Activation as a Promising Pharmacotherapeutic Strategy for Autism Spectrum Disorders
SI Deutsch, JA Burket - Medical Clinics, 2023 - medical.theclinics.com
The BALB/c mouse strain differed from comparator strains in terms of heightened sensitivity
to behavioral effects of MK-801 (dizocilpine), a noncompetitive NMDA receptor “open …
to behavioral effects of MK-801 (dizocilpine), a noncompetitive NMDA receptor “open …
Variations in antibody repertoires correlate with vaccine responses
An important challenge in vaccine development is to figure out why a vaccine succeeds in
some individuals and fails in others. Although antibody repertoires hold the key to answering …
some individuals and fails in others. Although antibody repertoires hold the key to answering …
[HTML][HTML] Brain age estimation at tract group level and its association with daily life measures, cardiac risk factors and genetic variants
Brain age can be estimated using different Magnetic Resonance Imaging (MRI) modalities
including diffusion MRI. Recent studies demonstrated that white matter (WM) tracts that …
including diffusion MRI. Recent studies demonstrated that white matter (WM) tracts that …
Investigating the shared genetic architecture and causal relationship between pain and neuropsychiatric disorders
M Chen, S Li, Z Zhu, C Dai, X Hao - Human Genetics, 2023 - Springer
Pain often occurs in parallel with neuropsychiatric disorders. However, the underlying
mechanisms and potential causality have not been well studied. We collected the genome …
mechanisms and potential causality have not been well studied. We collected the genome …
Genome‐wide association analysis of autism identified multiple loci that have been reported as strong signals for neuropsychiatric disorders
Autism is a common neurodevelopmental disorder with a moderate to a high degree of
heritability, but only a few common genetic variants that explain the heritability have been …
heritability, but only a few common genetic variants that explain the heritability have been …
[HTML][HTML] Integrative analyses of transcriptomes to explore common molecular effects of antipsychotic drugs
TTT Truong, CC Bortolasci, S Kidnapillai… - International Journal of …, 2022 - mdpi.com
There is little understanding of the underlying molecular mechanism (s) involved in the
clinical efficacy of antipsychotics for schizophrenia. This study integrated schizophrenia …
clinical efficacy of antipsychotics for schizophrenia. This study integrated schizophrenia …